12 December 2012
Vol 4, Issue 164
  • Contents

    • Focus

    • Perspective

      • Pluripotent Stem Cells: Immune to the Immune System?

        Understanding the immunogenic properties of embryonic and induced pluripotent stem cells will inform the immunosuppressive requirements for successful cell therapy.

    • Research Articles

    • Editors' Choice

      • Closing the Door on Malaria

        Treatment of human immunodeficiency virus infection enhances the effect of malaria treatment and may prevent recurrence.

      • Remembering the Variants in Alzheimer’s Disease

        Individuals with a rare variant of TREM2, which codes for an immune cell–related receptor, are more likely to develop Alzheimer’s disease.

      • Your Cells or Mine?

        A new phase I/II study compares autologous and allogeneic mesenchymal stem cells for treating ischemic cardiomyopathy.

About The Cover

Cover image expansion

ONLINE COVER Mouse on the Wire. A mouse hanging on a wire during a test of muscle strength. Mice with a mutant dystrophin gene, which have a muscular dystrophy–like disease, can only hang for about 20 seconds before they lose their grip and fall to the ground. An antisense oligonucleotide being developed to treat the disease in people only helps a little bit. But if the mice also receive the drug dantrolene (shown as the wire), they are stronger and can hang for 30 seconds or so. Kendall et al. found this powerful potentiator in a small molecule screen. It also works in human cells and may help patients with Duchenne's muscular dystrophy. [CREDIT: G. KENDALL/UCLA; IMAGES: M.C. MICELI, S. NELSON, E. MOKHONOVA, M. SPENCER]