Research ArticleParkinson’s Disease

α-Synuclein–Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons

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Science Translational Medicine  05 Dec 2012:
Vol. 4, Issue 163, pp. 163ra156
DOI: 10.1126/scitranslmed.3004676

Article Information

vol. 4 no. 163 163ra156

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication July 25, 2012
  • Accepted for publication November 14, 2012
  • .

Author Information

  1. Mickael Decressac1,*,
  2. Banafsheh Kadkhodaei2,
  3. Bengt Mattsson1,
  4. Ariadna Laguna2,
  5. Thomas Perlmann2,3 and
  6. Anders Björklund1,*
  1. 1Wallenberg Neuroscience Center, Department of Experimental Medical Sciences, Lund University, BMC A11, Lund 22184, Sweden.
  2. 2Ludwig Institute for Cancer Research, Karolinska Institutet, Stockholm S-171 77, Sweden.
  3. 3Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm S-171 77, Sweden.
  1. *To whom correspondence should be addressed. E-mail: Anders.Bjorklund{at}med.lu.se (A.B.); Mickael.Decressac{at}med.lu.se (M.D.)

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