Research ArticleDiagnostics

Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing

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Science Translational Medicine  28 Nov 2012:
Vol. 4, Issue 162, pp. 162ra154
DOI: 10.1126/scitranslmed.3004742

Article Information

vol. 4 no. 162 162ra154

PubMed: 
Print ISSN: 
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History: 
  • Received for publication August 7, 2012
  • Accepted for publication November 8, 2012

Author Information

  1. Rebecca J. Leary1,*,
  2. Mark Sausen1,*,
  3. Isaac Kinde1,*,
  4. Nickolas Papadopoulos1,
  5. John D. Carpten2,
  6. David Craig2,
  7. Joyce O’Shaughnessy3,
  8. Kenneth W. Kinzler1,
  9. Giovanni Parmigiani4,5,
  10. Bert Vogelstein1,
  11. Luis A. Diaz Jr.1, and
  12. Victor E. Velculescu1,
  1. 1Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA.
  2. 2Translational Genomics Research Institute, Phoenix, AZ 85044, USA.
  3. 3Baylor Sammons Cancer Center, Texas Oncology, US Oncology, Dallas, TX 75246, USA.
  4. 4Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  5. 5Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
  1. To whom correspondence should be addressed. E-mail: velculescu{at}jhmi.edu (V.E.V.); ldiaz1{at}jhmi.edu (L.A.D.)
  • * These authors contributed equally to this work.

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