Contents
Vol 4, Issue 162
Contents
Focus
- Time to Integrate Clinical and Research Informatics
Integration of electronic clinical and research data can streamline clinical research, patient care, and building of a learning health care system.
Research Articles
- Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex
A monoclonal antibody mimic of FGF21 exerts beneficial metabolic effects in obese monkeys.
- Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing
Massively parallel sequencing directly detects tumor-derived chromosomal alterations in plasma DNA from cancer patients.
- Tadalafil Alleviates Muscle Ischemia in Patients with Becker Muscular Dystrophy
The phosphodiesterase 5A inhibitor tadalafil restores normal blood flow regulation in exercising skeletal muscle of patients with Becker muscular dystrophy.
Editors' Choice
- The Clearly Misunderstood Case of ApoB-100
Apolipoprotein B-100 and low-density lipoprotein bind to bacterial lipoteichoic acid and interfere with the antibacterial immune response.
- Ear Power: Batteries Now Included
The inner ear displays an electrochemical gradient that can be used to power small electronic devices.
- Dissecting the Mystery Around Multiple Sclerosis
In an animal counterpart of multiple sclerosis, prostacyclin—a lipid eicosanoid—promotes neuronal remodeling and recovery.
- A Shot in the Arm for ART
Boosting the immune system of HIV patients with IFN-α suppresses HIV replication.