Contents

Contents

• Focus

  • Time to Integrate Clinical and Research Informatics

    By Irene L. Katzan, Richard A. Rudick

    Science Translational Medicine28 Nov 2012 : 162fs41 Full AccessRestricted Access

    Integration of electronic clinical and research data can streamline clinical research, patient care, and building of a learning health care system.

    • Abstract
    • Full Text
    • PDF

• Research Articles

  • Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex

    By Ian N. Foltz, Sylvia Hu, Chadwick King, Xinle Wu, Chaofeng Yang, Wei Wang, Jennifer Weiszmann, Jennitte Stevens, Jiyun Sunny Chen, Noi Nuanmanee, Jamila Gupte, Renee Komorowski, Laura Sekirov, Todd Hager, Taruna Arora, Hongfei Ge, Helene Baribault, Fen Wang, Jackie Sheng, Margaret Karow, Minghan Wang, Yongde Luo, Wallace McKeehan, Zhulun Wang, Murielle M. Véniant, Yang Li

    Science Translational Medicine28 Nov 2012 : 162ra153 Full AccessRestricted Access

    A monoclonal antibody mimic of FGF21 exerts beneficial metabolic effects in obese monkeys.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing

    By Rebecca J. Leary, Mark Sausen, Isaac Kinde, Nickolas Papadopoulos, John D. Carpten, David Craig, Joyce O’Shaughnessy, Kenneth W. Kinzler, Giovanni Parmigiani, Bert Vogelstein, Luis A. Diaz, Jr., Victor E. Velculescu

    Science Translational Medicine28 Nov 2012 : 162ra154 Full AccessRestricted Access

    Massively parallel sequencing directly detects tumor-derived chromosomal alterations in plasma DNA from cancer patients.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Tadalafil Alleviates Muscle Ischemia in Patients with Becker Muscular Dystrophy

    By Elizabeth A. Martin, Rita Barresi, Barry J. Byrne, Evgeny I. Tsimerinov, Bryan L. Scott, Ashley E. Walker, Swaminatha V. Gurudevan, Francine Anene, Robert M. Elashoff, Gail D. Thomas, Ronald G. Victor

    Science Translational Medicine28 Nov 2012 : 162ra155 Full AccessRestricted Access

    The phosphodiesterase 5A inhibitor tadalafil restores normal blood flow regulation in exercising skeletal muscle of patients with Becker muscular dystrophy.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • The Clearly Misunderstood Case of ApoB-100

    By Ernesto Oviedo-Orta

    Science Translational Medicine28 Nov 2012 : 162ec214 Full AccessRestricted Access

    Apolipoprotein B-100 and low-density lipoprotein bind to bacterial lipoteichoic acid and interfere with the antibacterial immune response.

    • Full Text

  • Ear Power: Batteries Now Included

    By Joshua D. Shrout

    Science Translational Medicine28 Nov 2012 : 162ec215 Full AccessRestricted Access

    The inner ear displays an electrochemical gradient that can be used to power small electronic devices.

    • Full Text

  • Dissecting the Mystery Around Multiple Sclerosis

    By Carsten Skarke

    Science Translational Medicine28 Nov 2012 : 162ec216 Full AccessRestricted Access

    In an animal counterpart of multiple sclerosis, prostacyclin—a lipid eicosanoid—promotes neuronal remodeling and recovery.

    • Full Text

  • A Shot in the Arm for ART

    By Ruanne V. Barnabas

    Science Translational Medicine28 Nov 2012 : 162ec217 Full AccessRestricted Access

    Boosting the immune system of HIV patients with IFN-α suppresses HIV replication.

    • Full Text