21 November 2012
Vol 4, Issue 161

About The Cover

Cover image expansion

ONLINE COVER Shine a Light. An immunohistochemical image showing neurons (green) in the rat motor cortex transduced with a light-activated chloride pump called halorhodopsin (Wykes et al.). Halorhodopsin is delivered by a lentiviral vector to the motor cortex of rats together with tetanus toxin, which induces focal epilepsy. When activated by laser light, halorhodopsin allows chloride ions to enter the transduced neurons, which become hyperpolarized resulting in reduced neuronal excitability and a decrease in epileptic activity. Astrocytes are stained orange, cell nuclei are blue. [CREDIT: L. MANTOAN AND D. KULLMANN]