Research ArticlePULMONARY EDEMA

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

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Science Translational Medicine  07 Nov 2012:
Vol. 4, Issue 159, pp. 159ra148
DOI: 10.1126/scitranslmed.3004276

Article Information

vol. 4 no. 159 159ra148

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication May 3, 2012
  • Accepted for publication September 28, 2012
  • .

Author Information

  1. Kevin S. Thorneloe1,*,
  2. Mui Cheung1,
  3. Weike Bao1,
  4. Hasan Alsaid1,
  5. Stephen Lenhard1,
  6. Ming-Yuan Jian2,
  7. Melissa Costell1,
  8. Kristeen Maniscalco-Hauk1,
  9. John A. Krawiec1,
  10. Alan Olzinski1,
  11. Earl Gordon1,
  12. Irina Lozinskaya1,
  13. Lou Elefante3,
  14. Pu Qin1,
  15. Daniel S. Matasic1,
  16. Chris James1,
  17. James Tunstead4,
  18. Brian Donovan5,
  19. Lorena Kallal6,
  20. Anna Waszkiewicz6,
  21. Kalindi Vaidya6,
  22. Elizabeth A. Davenport6,
  23. Jonathan Larkin3,
  24. Mark Burgert7,
  25. Linda N. Casillas8,
  26. Robert W. Marquis8,
  27. Guosen Ye1,
  28. Hilary S. Eidam1,
  29. Krista B. Goodman1,
  30. John R. Toomey1,
  31. Theresa J. Roethke1,
  32. Beat M. Jucker1,
  33. Christine G. Schnackenberg1,
  34. Mary I. Townsley2,
  35. John J. Lepore1 and
  36. Robert N. Willette1
  1. 1Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapy Area Unit, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA.
  2. 2Department of Physiology, University of South Alabama, Mobile, AL 36688, USA.
  3. 3Novel Targets Biopharm Discovery Unit, GlaxoSmithKline, King of Prussia, PA 19406, USA.
  4. 4Molecular and Cellular Technologies, GlaxoSmithKline, King of Prussia, PA 19406, USA.
  5. 5Screening and Compound Profiling, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA.
  6. 6Biological Reagents and Assay Development, GlaxoSmithKline, Collegeville, PA 19426, USA.
  7. 7Statistical Consulting Group, Quantitative Sciences, GlaxoSmithKline, King of Prussia, PA 19406, USA.
  8. 8Medicinal Chemistry Pattern Recognition Discovery Performance Unit, GlaxoSmithKline, Collegeville, PA 19426, USA.
  1. *To whom correspondence should be addressed. E-mail: Kevin.S.Thorneloe{at}gsk.com

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