Contents
Vol 4, Issue 159
Contents
Commentary
- Research Results: Preserving Newborn Blood Samples
The debate about retention and use of dried blood samples from newborn screening ignores the harm destruction may cause to biomedical research.
Perspective
- Improving Risk Assessment
A U.S. government initiative to engineer nonclinical cell-based models that mimic human biology may improve predictions of drug-related adverse events.
Research Articles
- A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice
An in vitro model of human pulmonary edema predicts drug toxicity and efficacy previously observed in humans.
- An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure
Transient receptor potential vanilloid 4 (TRPV4) channels are expressed in human heart failure lungs, which can be blocked to prevent and resolve heart failure–induced pulmonary edema.
- Human Melanoma Metastasis in NSG Mice Correlates with Clinical Outcome in Patients
The ability of melanomas to produce circulating tumor cells and to metastasize in immunocompromised mice correlates with their ability to form distant metastases in patients.
Editors' Choice
- Taking a Bite Out of Pain
Peptides in black mamba snake venom exert powerful analgesic effects by blocking acid-sensing ion channels in the mammalian nervous system.
- Milk of Amnesia
The concentrations of the anesthetic propofol used clinically are not toxic to neural precursor cells in culture.
- E-Selectin Gets HSCs Buzzing.
E-selectin inhibition may protect HSCs from chemo- and radiotherapy.
- Pneumonia Therapy Blazes a New TRAIL
A therapy that induces programmed cell death in alveolar macrophages helps mice survive pneumonia.
- Visible to the Naked Eye
A plasmonic biosensor detects extremely low concentrations of diagnostic markers for prostate cancer and HIV.
