Research ArticleInflammatory Bowel Diseases

Food-Grade Bacteria Expressing Elafin Protect Against Inflammation and Restore Colon Homeostasis

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Science Translational Medicine  31 Oct 2012:
Vol. 4, Issue 158, pp. 158ra144
DOI: 10.1126/scitranslmed.3004212

Article Information

vol. 4 no. 158 158ra144

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication April 23, 2012
  • Accepted for publication October 4, 2012
  • .

Author Information

  1. Jean-Paul Motta1,2,3,*,
  2. Luis G. Bermúdez-Humarán4,*,
  3. Céline Deraison1,2,3,
  4. Laurence Martin1,2,3,
  5. Corinne Rolland1,2,3,
  6. Perrine Rousset1,2,3,
  7. Jérôme Boue1,2,3,
  8. Gilles Dietrich1,2,3,
  9. Kevin Chapman5,
  10. Pascale Kharrat4,
  11. Jean-Pierre Vinel3,6,
  12. Laurent Alric3,6,
  13. Emmanuel Mas1,2,3,7,
  14. Jean-Michel Sallenave8,9,10,
  15. Philippe Langella4,* and
  16. Nathalie Vergnolle1,2,3,5,
  1. 1INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan (CPTP), Toulouse F-31300, France.
  2. 2CNRS, U5282, Toulouse F-31300, France.
  3. 3CPTP, Université de Toulouse, Université Paul Sabatier (UPS), Toulouse F-31300, France.
  4. 4Institut National de la Recherche Agronomique (INRA), UMR 1319 Micalis, Commensal and Probiotics-Host Interactions Laboratory, Domaine de Vilvert, 78352 Jouy-en-Josas Cedex, France.
  5. 5Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
  6. 6Pôle Digestif, CHU Purpan, Toulouse F-31059, France.
  7. 7Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital, Toulouse F-31059, France.
  8. 8Institut Pasteur, Unité de Défense Innée et Inflammation, Paris F-75015, France.
  9. 9INSERM U874, Paris F-75724, France.
  10. 10Universite Paris Diderot, Sorbonne Paris Cite, Cellule Pasteur F-75013, France.
  1. To whom correspondence should be addressed. E-mail: nathalie.vergnolle{at}inserm.fr
  • * These authors contributed equally to this work.

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