Contents
Vol 4, Issue 156
Contents
Perspectives
- Sisyphus and Translational Stroke Research
Testing of a stroke drug in cynomologus macaques and patients undergoing neurointervention may ultimately predict outcome in phase 2 or phase 3 clinical trials.
- Pancreas Cancer Meets the Thunder God
Natural product shows remarkable activity against pancreatic ductal adenocarcinoma across preclinical model systems.
Research Articles
- A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer
Minnelide prevents tumor formation, causes tumor regression, and increases survival in multiple models of pancreatic cancer.
- Methylation Subtypes and Large-Scale Epigenetic Alterations in Gastric Cancer
A large-scale genomic survey of epigenetic alterations in gastric cancer identifies clinically relevant molecular subgroups.
Editors' Choice
- Come Together: Antibody Linkers to Combat Hemophilia
A bispecific antibody mimics the missing clotting factor in hemophilia and may allow improved treatment.
- Transmission Favors HIV’s Ancestors
HIV prevention strategies may be able to focus on founder strains of the virus that appear to be preferentially transmitted.
- Ironing Out MYC in Prostate Cancer
A new imaging approach may be able to better detect some prostate cancers.
- A Warning Bell Tolls for Type 1 Diabetes
Toll-like receptor induces dysregulated interleukin-1β and interleukin-6 responses in subjects at risk for the development of type 1 diabetes.
Podcast
- Science Translational Medicine Podcast: 17 October 2012
In this podcast, Ashok Saluja discusses Minnelide, a potential new treatment for pancreatic cancer.