Contents

Contents

• Perspectives

  • Sisyphus and Translational Stroke Research

    By Patrick Lyden, Paul Lapchak

    Science Translational Medicine17 Oct 2012 : 156ps20 Full AccessRestricted Access

    Testing of a stroke drug in cynomologus macaques and patients undergoing neurointervention may ultimately predict outcome in phase 2 or phase 3 clinical trials.

    • Abstract
    • Full Text
    • PDF

  • Pancreas Cancer Meets the Thunder God

    By Sunil R. Hingorani, John D. Potter

    Science Translational Medicine17 Oct 2012 : 156ps21 Full AccessRestricted Access

    Natural product shows remarkable activity against pancreatic ductal adenocarcinoma across preclinical model systems.

    • Abstract
    • Full Text
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• Research Articles

  • A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer

    By Rohit Chugh, Veena Sangwan, Satish P. Patil, Vikas Dudeja, Rajinder K. Dawra, Sulagna Banerjee, Robert J. Schumacher, Bruce R. Blazar, Gunda I. Georg, Selwyn M. Vickers, Ashok K. Saluja

    Science Translational Medicine17 Oct 2012 : 156ra139 Full AccessRestricted Access

    Minnelide prevents tumor formation, causes tumor regression, and increases survival in multiple models of pancreatic cancer.

    • Editor's Summary
    • Abstract
    • Full Text
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  • Methylation Subtypes and Large-Scale Epigenetic Alterations in Gastric Cancer

    By Hermioni Zouridis, Niantao Deng, Tatiana Ivanova, Yansong Zhu, Bernice Wong, Dan Huang, Yong Hui Wu, Yingting Wu, Iain Beehuat Tan, Natalia Liem, Veena Gopalakrishnan, Qin Luo, Jeanie Wu, Minghui Lee, Wei Peng Yong, Liang Kee Goh, Bin Tean Teh, Steve Rozen, Patrick Tan

    Science Translational Medicine17 Oct 2012 : 156ra140 Full AccessRestricted Access

    A large-scale genomic survey of epigenetic alterations in gastric cancer identifies clinically relevant molecular subgroups.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Come Together: Antibody Linkers to Combat Hemophilia

    By Aaron B. Baker

    Science Translational Medicine17 Oct 2012 : 156ec186 Full AccessRestricted Access

    A bispecific antibody mimics the missing clotting factor in hemophilia and may allow improved treatment.

    • Full Text

  • Transmission Favors HIV’s Ancestors

    By Ruanne V. Barnabas

    Science Translational Medicine17 Oct 2012 : 156ec187 Full AccessRestricted Access

    HIV prevention strategies may be able to focus on founder strains of the virus that appear to be preferentially transmitted.

    • Full Text

  • Ironing Out MYC in Prostate Cancer

    By Chetan Bettegowda

    Science Translational Medicine17 Oct 2012 : 156ec188 Full AccessRestricted Access

    A new imaging approach may be able to better detect some prostate cancers.

    • Full Text

  • A Warning Bell Tolls for Type 1 Diabetes

    By Takahisa Nakamura

    Science Translational Medicine17 Oct 2012 : 156ec189 Full AccessRestricted Access

    Toll-like receptor induces dysregulated interleukin-1β and interleukin-6 responses in subjects at risk for the development of type 1 diabetes.

    • Full Text

• Podcast

  • Science Translational Medicine Podcast: 17 October 2012

    By Ashok K. Saluja, Angela Colmone

    Science Translational Medicine17 Oct 2012 : 156pc6 Full AccessRestricted Access

    In this podcast, Ashok Saluja discusses Minnelide, a potential new treatment for pancreatic cancer.

    • Abstract