10 October 2012
Vol 4, Issue 155
  • Contents

    • Commentary

      • Revolution Stalled

        Drug discovery is at a near standstill for psychiatric disorders such as schizophrenia, bipolar disorder, and depression.

    • Perspective

    • Research Articles

      • Human Neural Stem Cells Induce Functional Myelination in Mice with Severe Dysmyelination

        Transplanted banked human neural stem cells produce functional myelin detected by MRI in juvenile mice with severe dysmyelination.

      • Neural Stem Cell Engraftment and Myelination in the Human Brain

        Neural stem cell transplantation study suggests myelin formation in children with a severe hypomyelination disorder.

      • Immunotherapy Against HPV16/18 Generates Potent TH1 and Cytotoxic Cellular Immune Responses

        CD8+ T cells with cytolytic activity are induced after therapeutic human papillomavirus vaccination in humans.

    • Editors' Choice

      • Jack—Not Jill—Went up the Hill

        A subtle gender bias by faculty members favors male over female candidates in science.

      • There’s Node Place Like Home

        Delivering liver, thymus, or pancreatic cells to the lymph nodes can restore distant, diseased organ function.

      • From “Cheers” to Fears

        Alcohol-related changes in the prefrontal cortex may pave the way for posttraumatic stress disorder.

      • Tumors Vent Their Spleen

        The spleen may contribute to immune tolerance to tumors.

      • Antioxidizing Asthma

        Dietary intake of magnesium has a protective effect on childhood asthma.

About The Cover

Cover image expansion

ONLINE COVER Cupboard Is Bare. Prescriptions have begun to expire for patients suffering from psychiatric disorders. Despite the astonishing advances of the 1940's, recent drug discovery efforts for schizophrenia, bipolar disorder, and depression have been disappointing, and Pharma has largely left the building. In this week's Commentary, Hyman discusses the history and science behind this derailing and suggests that next-generation genetic and genomic approaches, engineering of neuronal-circuit models in vitro, and audacity on the part of industry and regulators may right the path to therapeutic innovation. In his Perspective, Insel imagines a new culture in which translation is accelerated by standardization, integration, and sharing of data through new partnerships. This culture shift should enhance our understanding of psychiatric disease biology and thus spur the discovery of effective interventions for mental illness. [CREDIT: ISTOCKPHOTO]