Contents

Contents

• Commentary

  • Revolution Stalled

    By Steven E. Hyman

    Science Translational Medicine10 Oct 2012 : 155cm11 Full AccessRestricted Access

    Drug discovery is at a near standstill for psychiatric disorders such as schizophrenia, bipolar disorder, and depression.

    • Abstract
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• Perspective

  • Next-Generation Treatments for Mental Disorders

    By Thomas R. Insel

    Science Translational Medicine10 Oct 2012 : 155ps19 Full AccessRestricted Access

    Despite a retreat by industry from developing new psychiatric medications, recent research reveals new opportunities for progress.

    • Abstract
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• Research Articles

  • Human Neural Stem Cells Induce Functional Myelination in Mice with Severe Dysmyelination

    By Nobuko Uchida, Kevin Chen, Monika Dohse, Kelly D. Hansen, Justin Dean, Joshua R. Buser, Art Riddle, Douglas J. Beardsley, Ying Wan, Xi Gong, Thuan Nguyen, Brian J. Cummings, Aileen J. Anderson, Stanley J. Tamaki, Ann Tsukamoto, Irving L. Weissman, Steven G. Matsumoto, Larry S. Sherman, Christopher D. Kroenke, Stephen A. Back

    Science Translational Medicine10 Oct 2012 : 155ra136 Full AccessRestricted Access

    Transplanted banked human neural stem cells produce functional myelin detected by MRI in juvenile mice with severe dysmyelination.

    • Editor's Summary
    • Abstract
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  • Neural Stem Cell Engraftment and Myelination in the Human Brain

    By Nalin Gupta, Roland G. Henry, Jonathan Strober, Sang-Mo Kang, Daniel A. Lim, Monica Bucci, Eduardo Caverzasi, Laura Gaetano, Maria Luisa Mandelli, Tamara Ryan, Rachel Perry, Jody Farrell, Rita J. Jeremy, Mary Ulman, Stephen L. Huhn, A. James Barkovich, David H. Rowitch

    Science Translational Medicine10 Oct 2012 : 155ra137 Full AccessRestricted Access

    Neural stem cell transplantation study suggests myelin formation in children with a severe hypomyelination disorder.

    • Editor's Summary
    • Abstract
    • Full Text
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  • Immunotherapy Against HPV16/18 Generates Potent T_H1 and Cytotoxic Cellular Immune Responses

    By Mark L. Bagarazzi, Jian Yan, Matthew P. Morrow, Xuefei Shen, R. Lamar Parker, Jessica C. Lee, Mary Giffear, Panyupa Pankhong, Amir S. Khan, Kate E. Broderick, Christine Knott, Feng Lin, Jean D. Boyer, Ruxandra Draghia-Akli, C. Jo White, J. Joseph Kim, David B. Weiner, Niranjan Y. Sardesai

    Science Translational Medicine10 Oct 2012 : 155ra138 Full AccessRestricted Access

    CD8⁺ T cells with cytolytic activity are induced after therapeutic human papillomavirus vaccination in humans.

    • Editor's Summary
    • Abstract
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• Editors' Choice

  • Jack—Not Jill—Went up the Hill

    By Niroshana Anandasabapathy

    Science Translational Medicine10 Oct 2012 : 155ec181 Full AccessRestricted Access

    A subtle gender bias by faculty members favors male over female candidates in science.

    • Full Text

  • There’s Node Place Like Home

    By Joel H. Collier

    Science Translational Medicine10 Oct 2012 : 155ec182 Full AccessRestricted Access

    Delivering liver, thymus, or pancreatic cells to the lymph nodes can restore distant, diseased organ function.

    • Full Text

  • From “Cheers” to Fears

    By George A. Mashour

    Science Translational Medicine10 Oct 2012 : 155ec183 Full AccessRestricted Access

    Alcohol-related changes in the prefrontal cortex may pave the way for posttraumatic stress disorder.

    • Full Text

  • Tumors Vent Their Spleen

    By Matthias Nahrendorf

    Science Translational Medicine10 Oct 2012 : 155ec184 Full AccessRestricted Access

    The spleen may contribute to immune tolerance to tumors.

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  • Antioxidizing Asthma

    By Marina Reznik

    Science Translational Medicine10 Oct 2012 : 155ec185 Full AccessRestricted Access

    Dietary intake of magnesium has a protective effect on childhood asthma.

    • Full Text