Research ArticleFragile X Syndrome

Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABAB Receptors with Arbaclofen

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Science Translational Medicine  19 Sep 2012:
Vol. 4, Issue 152, pp. 152ra128
DOI: 10.1126/scitranslmed.3004218

Article Information

vol. 4 no. 152 152ra128

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication April 24, 2012
  • Accepted for publication August 31, 2012
  • .

Author Information

  1. Christina Henderson1,
  2. Lasani Wijetunge2,
  3. Mika Nakamoto Kinoshita3,
  4. Matthew Shumway1,
  5. Rebecca S. Hammond1,
  6. Friso R. Postma1,
  7. Christopher Brynczka1,
  8. Roger Rush1,
  9. Alexia Thomas4,
  10. Richard Paylor4,
  11. Stephen T. Warren3,
  12. Peter W. Vanderklish5,
  13. Peter C. Kind2,
  14. Randall L. Carpenter1,
  15. Mark F. Bear6 and
  16. Aileen M. Healy1,*
  1. 1Seaside Therapeutics Inc., Cambridge, MA 02139, USA.
  2. 2The Patrick Wild Centre, University of Edinburgh, Edinburgh EH8 9XD, UK.
  3. 3Department of Human Genetics, Emory University, Atlanta, GA 30322, USA.
  4. 4Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  5. 5Department of Neurobiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  6. 6Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  1. *To whom correspondence should be addressed. E-mail: ahealy{at}seasidetherapeutics.com

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