Research ArticleFragile X Syndrome

Effects of STX209 (Arbaclofen) on Neurobehavioral Function in Children and Adults with Fragile X Syndrome: A Randomized, Controlled, Phase 2 Trial

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Science Translational Medicine  19 Sep 2012:
Vol. 4, Issue 152, pp. 152ra127
DOI: 10.1126/scitranslmed.3004214

Article Information

vol. 4 no. 152 152ra127

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication April 24, 2012
  • Accepted for publication July 30, 2012
  • .

Author Information

  1. Elizabeth M. Berry-Kravis1,
  2. David Hessl2,
  3. Barbara Rathmell3,
  4. Peter Zarevics3,
  5. Maryann Cherubini3,
  6. Karen Walton-Bowen3,
  7. Yi Mu4,
  8. Danh V. Nguyen4,
  9. Joseph Gonzalez-Heydrich5,
  10. Paul P. Wang3,*,
  11. Randall L. Carpenter3,
  12. Mark F. Bear6 and
  13. Randi J. Hagerman7
  1. 1Departments of Pediatrics, Neurological Sciences, and Biochemistry, Rush University Medical Center, Chicago, IL 60612, USA.
  2. 2Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, and Department of Psychiatry and Behavioral Sciences, University of California Davis Medical Center, Sacramento, CA 95817, USA.
  3. 3Seaside Therapeutics Inc., Cambridge, MA 02139, USA.
  4. 4Division of Biostatistics, Department of Public Health Sciences, University of California, Davis, Sacramento, CA 95817, USA.
  5. 5Department of Psychiatry, Children’s Hospital Boston, Boston, MA 02115, USA.
  6. 6Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  7. 7Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, and Department of Pediatrics, University of California Davis Medical Center, Sacramento, CA 95817, USA.
  1. *To whom correspondence should be addressed. E-mail: pwang{at}seasidetherapeutics.com

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