19 September 2012
Vol 4, Issue 152

About The Cover

Cover image expansion

ONLINE COVER The Fragile X Chromosome. Fragile X syndrome, a common cause of intellectual impairment and autism, is caused by excess repetitions of the three-letter code for CGG, which impair expression of a gene required for brain development. These repeats result in a constriction near the ends of the X chromosome, giving the impression that the tip could easily break off and inspiring the name of the disease. In this issue, two research articles (Berry-Kravis et al. and Henderson et al.) report that arbaclofen, which mimics the inhibitory neurotransmitter GABA, can improve neuronal function in mouse models and fragile X patients. [CREDIT: B. STRAUCH/SCIENCE TRANSLATIONAL MEDICINE]