Contents

Contents

• Perspectives

  • Patient-Empowerment Interactive Technologies

    By Carol S. Bruggers, Roger A. Altizer, Robert R. Kessler, Craig B. Caldwell, Kurt Coppersmith, Laura Warner, Brandon Davies, Wade Paterson, Jordan Wilcken, Troy A. D’Ambrosio, Massiell L. German, Glen R. Hanson, Lynn A. Gershan, Julie R. Korenberg, Grzegorz Bulaj

    Science Translational Medicine19 Sep 2012 : 152ps16 Full AccessRestricted Access

    Health-promoting videogames are emerging as nonpharmacological tools to help patients manage their diseases.

    • Abstract
    • Full Text
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  • Childhood Disorders of the Synapse: Challenges and Opportunities

    By Virginia Hughes, Morgan Sheng, Huda Zoghbi

    Science Translational Medicine19 Sep 2012 : 152ps17 Full AccessRestricted Access

    New research directions are needed to accelerate the development of new treatments for autism and related disorders.

    • Abstract
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• Research Articles

  • Effects of STX209 (Arbaclofen) on Neurobehavioral Function in Children and Adults with Fragile X Syndrome: A Randomized, Controlled, Phase 2 Trial

    By Elizabeth M. Berry-Kravis, David Hessl, Barbara Rathmell, Peter Zarevics, Maryann Cherubini, Karen Walton-Bowen, Yi Mu, Danh V. Nguyen, Joseph Gonzalez-Heydrich, Paul P. Wang, Randall L. Carpenter, Mark F. Bear, Randi J. Hagerman

    Science Translational Medicine19 Sep 2012 : 152ra127 Full AccessRestricted Access

    Administration of a selective GABA_B agonist to individuals with fragile X syndrome improves their deficits in social avoidance, a core symptom of the disease.

    • Editor's Summary
    • Abstract
    • Full Text
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  • Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABA_B Receptors with Arbaclofen

    By Christina Henderson, Lasani Wijetunge, Mika Nakamoto Kinoshita, Matthew Shumway, Rebecca S. Hammond, Friso R. Postma, Christopher Brynczka, Roger Rush, Alexia Thomas, Richard Paylor, Stephen T. Warren, Peter W. Vanderklish, Peter C. Kind, Randall L. Carpenter, Mark F. Bear, Aileen M. Healy

    Science Translational Medicine19 Sep 2012 : 152ra128 Full AccessRestricted Access

    Pharmacological activation of the GABA_B receptor with arbaclofen in a mouse model of fragile X syndrome corrects neuronal defects associated with the disease.

    • Editor's Summary
    • Abstract
    • Full Text
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  • A Paper-Based Multiplexed Transaminase Test for Low-Cost, Point-of-Care Liver Function Testing

    By Nira R. Pollock, Jason P. Rolland, Shailendra Kumar, Patrick D. Beattie, Sidhartha Jain, Farzad Noubary, Vicki L. Wong, Rebecca A. Pohlmann, Una S. Ryan, George M. Whitesides

    Science Translational Medicine19 Sep 2012 : 152ra129 Full AccessRestricted Access

    A paper-based, multiplexed microfluidic assay allows rapid, semiquantitative, visual measurement of transaminases in clinical specimens.

    • Editor's Summary
    • Abstract
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• Editors' Choice

  • Restoring Rhythm in the Broken Heart

    By Aaron B. Baker

    Science Translational Medicine19 Sep 2012 : 152ec168 Full AccessRestricted Access

    Gene transfer of a gap junction protein connexin 43 may reduce the risk of arrhythmia after heart attack.

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  • Tuberculosis Screening Method in Question

    By Ruanne Barnabas

    Science Translational Medicine19 Sep 2012 : 152ec169 Full AccessRestricted Access

    Antiretroviral therapy results in poor sensitivity of tuberculosis screening.

    • Full Text

  • Fruit Flies Create a Buzz About Hearing

    By Chetan Bettegowda

    Science Translational Medicine19 Sep 2012 : 152ec170 Full AccessRestricted Access

    Studies in Drosophila highlight new genes that may play a role in hereditary hearing loss in humans.

    • Full Text

  • Stirrings in the Graveyard

    By Carolyn S. Calfee

    Science Translational Medicine19 Sep 2012 : 152ec171 Full AccessRestricted Access

    Angiopoietin-2 may be an attractive therapeutic target in severe sepsis.

    • Full Text