Contents
Vol 4, Issue 152
Contents
Perspectives
- Patient-Empowerment Interactive Technologies
Health-promoting videogames are emerging as nonpharmacological tools to help patients manage their diseases.
- Childhood Disorders of the Synapse: Challenges and Opportunities
New research directions are needed to accelerate the development of new treatments for autism and related disorders.
Research Articles
- Effects of STX209 (Arbaclofen) on Neurobehavioral Function in Children and Adults with Fragile X Syndrome: A Randomized, Controlled, Phase 2 Trial
Administration of a selective GABAB agonist to individuals with fragile X syndrome improves their deficits in social avoidance, a core symptom of the disease.
- Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABAB Receptors with Arbaclofen
Pharmacological activation of the GABAB receptor with arbaclofen in a mouse model of fragile X syndrome corrects neuronal defects associated with the disease.
- A Paper-Based Multiplexed Transaminase Test for Low-Cost, Point-of-Care Liver Function Testing
A paper-based, multiplexed microfluidic assay allows rapid, semiquantitative, visual measurement of transaminases in clinical specimens.
Editors' Choice
- Restoring Rhythm in the Broken Heart
Gene transfer of a gap junction protein connexin 43 may reduce the risk of arrhythmia after heart attack.
- Tuberculosis Screening Method in Question
Antiretroviral therapy results in poor sensitivity of tuberculosis screening.
- Fruit Flies Create a Buzz About Hearing
Studies in Drosophila highlight new genes that may play a role in hereditary hearing loss in humans.
- Stirrings in the Graveyard
Angiopoietin-2 may be an attractive therapeutic target in severe sepsis.