Anthrax Vaccine–Induced Antibodies Provide Cross-Species Prediction of Survival to Aerosol Challenge

Michael P. Fay; Dean A. Follmann; Freyja Lynn; Jarad M. Schiffer; Gregory V. Stark; Robert Kohberger; Conrad P. Quinn; Edwin O. Nuzum

doi:10.1126/scitranslmed.3004073

Research ArticleAnthrax

Anthrax Vaccine–Induced Antibodies Provide Cross-Species Prediction of Survival to Aerosol Challenge

Michael P. Fay¹,*,
Dean A. Follmann¹,
Freyja Lynn²,†,
Jarad M. Schiffer³,‡,
Gregory V. Stark⁴,
Robert Kohberger⁵,§,
Conrad P. Quinn³,‡ and
Edwin O. Nuzum²

¹Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive, Bethesda, MD 20892–7630, USA.
²Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, 6610 Rockledge Drive, Bethesda, MD 20892–6604, USA.
³Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA.
⁴Battelle, 505 King Avenue, Columbus, OH 43201, USA.
⁵Blair & Co., Greenwich, CT 06830, USA.

↵*To whom correspondence should be addressed. E-mail: mfay{at}niaid.nih.gov

↵† Present address: Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, 9000 Rockville Pike, Bethesda, MD 20892, USA.
↵‡ The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.
↵§ Deceased. We dedicate this paper to him.

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Science Translational Medicine 12 Sep 2012:
Vol. 4, Issue 151, pp. 151ra126
DOI: 10.1126/scitranslmed.3004073

Michael P. Fay

1Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive, Bethesda, MD 20892–7630, USA.

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For correspondence: mfay@niaid.nih.gov

Dean A. Follmann

1Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive, Bethesda, MD 20892–7630, USA.

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Freyja Lynn

2Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, 6610 Rockledge Drive, Bethesda, MD 20892–6604, USA.

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Jarad M. Schiffer

3Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA.

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Gregory V. Stark

4Battelle, 505 King Avenue, Columbus, OH 43201, USA.

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Robert Kohberger

5Blair & Co., Greenwich, CT 06830, USA.

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Conrad P. Quinn

3Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA.

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Edwin O. Nuzum

2Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, 6610 Rockledge Drive, Bethesda, MD 20892–6604, USA.

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Anthrax Vaccine–Induced Antibodies Provide Cross-Species Prediction of Survival to Aerosol Challenge

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