Emtricitabine-Tenofovir Concentrations and Pre-Exposure Prophylaxis Efficacy in Men Who Have Sex with Men

Peter L. Anderson; David V. Glidden; Albert Liu; Susan Buchbinder; Javier R. Lama; Juan Vicente Guanira; Vanessa McMahan; Lane R. Bushman; Martín Casapía; Orlando Montoya-Herrera; Valdilea G. Veloso; Kenneth H. Mayer; Suwat Chariyalertsak; Mauro Schechter; Linda-Gail Bekker; Esper Georges Kallás; Robert M. Grant; For the iPrEx Study Team

doi:10.1126/scitranslmed.3004006

Research ArticleHIV

Emtricitabine-Tenofovir Concentrations and Pre-Exposure Prophylaxis Efficacy in Men Who Have Sex with Men

Peter L. Anderson¹,
David V. Glidden²,
Albert Liu³,
Susan Buchbinder²,³,
Javier R. Lama⁴,⁵,
Juan Vicente Guanira⁵,
Vanessa McMahan⁶,
Lane R. Bushman¹,
Martín Casapía⁷,
Orlando Montoya-Herrera⁸,
Valdilea G. Veloso⁹,
Kenneth H. Mayer¹⁰,¹¹,
Suwat Chariyalertsak¹²,
Mauro Schechter¹³,
Linda-Gail Bekker¹⁴,
Esper Georges Kallás¹⁵,¹⁶,
Robert M. Grant²,⁶,* and
For the iPrEx Study Team

¹University of Colorado Denver, Aurora, CO 80045, USA.
²University of California, San Francisco, San Francisco, CA 94143, USA.
³HIV Research Section, San Francisco Department of Public Health, San Francisco, CA 94102, USA.
⁴Investigaciones Medicas en Salud, Lima 14, Peru.
⁵Asociación Civil Impacta Salud y Educación, Lima, Peru.
⁶Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA.
⁷Asociación Civil Selva Amazónica, Iquitos, Maynas, Peru.
⁸Fundación Ecuatoriana Equidad, Guayaquil-Guayas, Ecuador.
⁹Instituto de Pesquisa Clinica Evandro Chagas, Fundação Oswaldo Cruz, Manguinhos, Rio de Janeiro CEP 21040-900, Brazil.
¹⁰Brown University, Providence, RI 02912, USA.
¹¹Fenway Institute, Fenway Health, Boston, MA 02215, USA.
¹²Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
¹³Projeto Praça Onze, Hospital Escola São Francisco de Assis, Universidade Federal do Rio de Janeiro, Rio de Janeiro CEP 20.210-030, Brazil.
¹⁴Desmond Tutu HIV Centre and Department of Medicine, University of Cape Town, Cape Town 7925, South Africa.
¹⁵Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, SP 05403-000, Brazil.
¹⁶Instituto de Investigação em Imunologia, Cerqueira Cesar, São Paulo, SP CEP 05403-900, Brazil.

↵*To whom correspondence should be addressed. E-mail: robert.grant{at}ucsf.edu

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Science Translational Medicine 12 Sep 2012:
Vol. 4, Issue 151, pp. 151ra125
DOI: 10.1126/scitranslmed.3004006

Peter L. Anderson

1University of Colorado Denver, Aurora, CO 80045, USA.

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David V. Glidden

2University of California, San Francisco, San Francisco, CA 94143, USA.

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Albert Liu

3HIV Research Section, San Francisco Department of Public Health, San Francisco, CA 94102, USA.

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Susan Buchbinder

2University of California, San Francisco, San Francisco, CA 94143, USA.

3HIV Research Section, San Francisco Department of Public Health, San Francisco, CA 94102, USA.

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Javier R. Lama

4Investigaciones Medicas en Salud, Lima 14, Peru.

5Asociación Civil Impacta Salud y Educación, Lima, Peru.

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Juan Vicente Guanira

5Asociación Civil Impacta Salud y Educación, Lima, Peru.

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Vanessa McMahan

6Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA.

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Lane R. Bushman

1University of Colorado Denver, Aurora, CO 80045, USA.

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Martín Casapía

7Asociación Civil Selva Amazónica, Iquitos, Maynas, Peru.

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Orlando Montoya-Herrera

8Fundación Ecuatoriana Equidad, Guayaquil-Guayas, Ecuador.

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Valdilea G. Veloso

9Instituto de Pesquisa Clinica Evandro Chagas, Fundação Oswaldo Cruz, Manguinhos, Rio de Janeiro CEP 21040-900, Brazil.

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Kenneth H. Mayer

10Brown University, Providence, RI 02912, USA.

11Fenway Institute, Fenway Health, Boston, MA 02215, USA.

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Suwat Chariyalertsak

12Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.

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Mauro Schechter

13Projeto Praça Onze, Hospital Escola São Francisco de Assis, Universidade Federal do Rio de Janeiro, Rio de Janeiro CEP 20.210-030, Brazil.

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Linda-Gail Bekker

14Desmond Tutu HIV Centre and Department of Medicine, University of Cape Town, Cape Town 7925, South Africa.

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Esper Georges Kallás

15Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo, SP 05403-000, Brazil.

16Instituto de Investigação em Imunologia, Cerqueira Cesar, São Paulo, SP CEP 05403-900, Brazil.

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Robert M. Grant

2University of California, San Francisco, San Francisco, CA 94143, USA.

6Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA.

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For correspondence: robert.grant@ucsf.edu

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Emtricitabine-Tenofovir Concentrations and Pre-Exposure Prophylaxis Efficacy in Men Who Have Sex with Men

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