Research ArticleTuberculosis

Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis

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Science Translational Medicine  05 Sep 2012:
Vol. 4, Issue 150, pp. 150ra121
DOI: 10.1126/scitranslmed.3004395

Article Information

vol. 4 no. 150 150ra121

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication May 29, 2012
  • Accepted for publication July 20, 2012
  • .

Author Information

  1. João Neres1,2,3,
  2. Florence Pojer1,2,
  3. Elisabetta Molteni1,4,
  4. Laurent R. Chiarelli1,4,
  5. Neeraj Dhar1,2,
  6. Stefanie Boy-Röttger1,2,
  7. Silvia Buroni1,4,
  8. Elizabeth Fullam1,2,*,
  9. Giulia Degiacomi1,4,,
  10. Anna Paola Lucarelli4,,
  11. Randy J. Read5,
  12. Giuseppe Zanoni6,
  13. Dale E. Edmondson7,
  14. Edda De Rossi1,4,
  15. Maria Rosalia Pasca1,4,
  16. John D. McKinney1,2,
  17. Paul J. Dyson3,
  18. Giovanna Riccardi1,4,
  19. Andrea Mattevi4,
  20. Stewart T. Cole1,2,§ and
  21. Claudia Binda1,4,§
  1. 1More Medicines for Tuberculosis (MM4TB) Consortium.
  2. 2Global Health Institute, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
  3. 3Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
  4. 4Department of Biology and Biotechnology, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy.
  5. 5Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK.
  6. 6Department of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.
  7. 7Department of Biochemistry, Emory University, Atlanta, GA 30322, USA.
  1. §To whom correspondence should be addressed. E-mail: claudia.binda{at}unipv.it (C.B.); stewart.cole{at}epfl.ch (S.T.C.)
  • * Present address: School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

  • Present address: Department of Biochemistry, Comenius University, Mlynska dolina, 84215 Bratislava, Slovak Republic.

  • Present address: Center for Nano Science and Technology of IIT@PoliMi, Via Pascoli 70/3, 20133 Milano, Italy.

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