Contents
Vol 4, Issue 150
Contents
Focus
- Bridging the Gap Between a TB Drug and Its Target
A promising new TB drug co-crystallized with its mycobacterial target provides a platform for structure-based design that will improve TB drug development (Neres et al.).
- The Nexus of Aβ, Aging, and Sleep
Roh et al. report a positive feedback loop between sleep-wake irregularities and aggregation of β-amyloid (Aβ) peptide, suggesting that sleep alterations could be an early event in Alzheimer’s disease (AD).
- Regulatory Science Innovation: A Rate-Limiting Step in Translation
Sustained funding for academic regulatory science will drive innovation and implementation, forge a viable career path, and build an educated workforce.
Research Articles
- Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis
The crystal structure of the mycobacterial DprE1 reveals how the TB drug benzothiazinone BTZ043 blocks this microbial enzyme target.
- Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of β-Amyloid in Mice with Alzheimer’s Disease Pathology
Decreased sleep and attenuation of circadian fluctuations in Aβ reflect amyloid-associated pathology in Alzheimer’s disease.
- An Intravaginal Ring That Releases the NNRTI MIV-150 Reduces SHIV Transmission in Macaques
An intravaginal ring loaded with the NNRTI MIV-150 prevents transmission of the HIV/SIV chimera SHIV-RT in macaques.
Editors' Choice
- Seeing Double to Recognize TB
Detection of double-stranded Mycobacterium tuberculosis DNA by the immune system leads to pathogen destruction via autophagy.
- How Much Alcohol Is Too Much?
Moderate alcohol blood concentrations hamper the development of new neurons in the adult rat hippocampus.
- Immune from It All
What our lungs can learn from our guts about mitigating bacterial infections.
