Research ArticleLeukemia

Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia

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Science Translational Medicine  29 Aug 2012:
Vol. 4, Issue 149, pp. 149ra118
DOI: 10.1126/scitranslmed.3004315

Article Information

vol. 4 no. 149 149ra118

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History: 
  • Received for publication May 15, 2012
  • Accepted for publication July 31, 2012

Author Information

  1. Max Jan1,*,
  2. Thomas M. Snyder2,*,
  3. M. Ryan Corces-Zimmerman1,*,
  4. Paresh Vyas3,
  5. Irving L. Weissman1,*,
  6. Stephen R. Quake2,* and
  7. Ravindra Majeti1,4,*,
  1. 1Program in Cancer Biology, Cancer Institute, Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
  2. 2Department of Bioengineering and Howard Hughes Medical Institute, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
  3. 3MRC Molecular Haematology Unit and Department of Haematology, Weatherall Institute of Molecular Medicine, and University of Oxford and Oxford University Hospitals NHS Trust, Oxford OX3 9DS, UK.
  4. 4Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
  1. To whom correspondence should be addressed. E-mail: rmajeti{at}stanford.edu
  • * These authors contributed equally to this work.

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