Contents
Vol 4, Issue 148
Contents
Focus
- It Ain’t Over ‘Til the Fat Lady Sings
The antiatherogenic drug nicotinic acid (niacin) has antidyslipidemic effects independent of free fatty acid suppression mediated by its receptor HCA2 (GPR109A) (Lauring et al., this issue).
Research Articles
- Niacin Lipid Efficacy Is Independent of Both the Niacin Receptor GPR109A and Free Fatty Acid Suppression
GPR109A is not the target mediating niacin’s lipid efficacy and the free fatty acid hypothesis does not explain niacin’s mechanism of action.
- Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing
Tracking a hospital outbreak of carbapenem-resistant Klebsiella pneumoniae with whole-genome sequencing revealed its origin and probable modes of transmission.
- Targeted Disruption of the BCL9/β-Catenin Complex Inhibits Oncogenic Wnt Signaling
Blocking BCL9/β-catenin interaction with a stapled peptide inhibits Wnt-dependent transcription and suppresses growth and metastasis in colon cancer and multiple myeloma.
Review
- Engineering Approaches to Immunotherapy
The rapidly evolving field of immunoengineering will bring new design strategies to clinical immunology.
Editors' Choice
- Measuring the Benefits of HPV Vaccination
Costs of HPV disease in the United States could be offset by vaccination.
- A Window of Opportunity for Alzheimer’s Disease
Patients with hereditary forms of Alzheimer’s disease show changes in the brain more than two decades before symptom onset.
- A Breath of Fresh Alveoli
A case report suggests that the adult human lung is capable of partial regrowth after lung resection.
- A Sweet Way to Construct Vascular Networks
Sacrificial networks of carbohydrate glass form vascular channels in engineered materials.
- Microbial Manipulation of Metabolism
The human gut microbiome changes during pregnancy and resembles that associated with metabolic syndrome.
