Research ArticleCancer

Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4

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Science Translational Medicine  15 Aug 2012:
Vol. 4, Issue 147, pp. 147ra112
DOI: 10.1126/scitranslmed.3003778

Article Information

vol. 4 no. 147 147ra112

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 27, 2012
  • Accepted for publication June 21, 2012
  • .

Author Information

  1. Yin Ren1,*,
  2. Hiu Wing Cheung2,3,*,
  3. Geoffrey von Maltzhan1,
  4. Amit Agrawal1,
  5. Glenn S. Cowley3,
  6. Barbara A. Weir3,
  7. Jesse S. Boehm3,
  8. Pablo Tamayo3,
  9. Alison M. Karst2,
  10. Joyce F. Liu2,
  11. Michelle S. Hirsch4,
  12. Jill P. Mesirov3,5,
  13. Ronny Drapkin2,4,
  14. David E. Root3,
  15. Justin Lo1,
  16. Valentina Fogal6,7,
  17. Erkki Ruoslahti6,7,
  18. William C. Hahn2,3,8,9, and
  19. Sangeeta N. Bhatia1,3,5,8,10,
  1. 1Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  2. 2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  3. 3Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  4. 4Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  5. 5Electrical Engineering and Computer Science and DF2avid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  6. 6Center for Nanomedicine, Sanford-Burnham Medical Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106–9610, USA.
  7. 7Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
  8. 8Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  9. 9Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  10. 10Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
  1. To whom correspondence should be addressed. E-mail: william_hahn{at}dfci.harvard.edu (W.C.H.); sbhatia{at}mit.edu (S.N.B.)
  • * These authors contributed equally to this work.

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