Research ArticleCerebrospinal Fluid Circulation
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
- Jeffrey J. Iliff1,*,
- Minghuan Wang1,2,
- Yonghong Liao1,
- Benjamin A. Plogg1,
- Weiguo Peng1,
- Georg A. Gundersen3,4,
- Helene Benveniste5,6,
- G. Edward Vates1,
- Rashid Deane1,
- Steven A. Goldman1,7,
- Erlend A. Nagelhus3,4 and
- Maiken Nedergaard1,*
- 1Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA.
- 2Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
- 3Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway.
- 4Centre for Molecular Biology and Neuroscience, Letten Centre, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.
- 5Department of Radiology, Health Science Center, Stony Brook University, Stony Brook, NY 11794, USA.
- 6Department of Anesthesiology, Health Science Center, Stony Brook University, Stony Brook, NY 11794, USA.
- 7Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA.
- ↵*To whom correspondence should be addressed. E-mail: jeffrey_iliff{at}urmc.rochester.edu (J.J.I.); nedergaard{at}urmc.rochester.edu (M.N.)
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Science Translational Medicine 15 Aug 2012:
Vol. 4, Issue 147, pp. 147ra111
DOI: 10.1126/scitranslmed.3003748
