Contents
Vol 4, Issue 147
Contents
Focus
- Balancing Tissue and Tumor Formation in Regenerative Medicine
A set of general principles can guide preclinical testing strategies for evaluating the tumorigenicity of regenerative medicine products.
- Brain Superhighways
Gliovascular pathways guide water flow and solute clearance in the brain.
Research Articles
- A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
Cerebrospinal fluid flows through channels around brain blood vessels that are bounded by astrocytic endfeet, mediated by water transport through aquaporin-4.
- Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Oncogene ID4
Tumor-penetrating siRNA nanocomplexes credential ID4 as a therapeutic oncogene target in human ovarian cancer.
- Proteasome Inhibition Alleviates SNARE-Dependent Neurodegeneration
Neurodegeneration in a mouse model is abrogated by proteasome inhibitors that reverse impaired SNARE-complex assembly.
- Elicitation of Broadly Neutralizing Influenza Antibodies in Animals with Previous Influenza Exposure
Broadly neutralizing antibodies to influenza can be elicited by vaccination in animals previously infected or immunized by the virus.
Editors' Choice
- Cutting the Supply Lines in Cancer and Retinal Disease
Inhibition of a new pathway may provide a means to block neovascularization in cancer and ocular disease.
- Sleepy Time for Tumor Cells
General anesthetics inhibit matrix metalloproteinase-9 and limit invasiveness of colon cancer cells.
- The Bone Marrow: Friend or Foe of the Heart?
The bone marrow may play a major role in atherosclerosis and its complications.
- No More Gasping for Air with GSPE
Grape seed extract suppresses inflammation and airway hyperresponsiveness in a murine model of asthma.
