Research ArticleRheumatoid Arthritis

Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis

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Science Translational Medicine  08 Aug 2012:
Vol. 4, Issue 146, pp. 146ra108
DOI: 10.1126/scitranslmed.3003717

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  • Metabolic environment in inflammation

    Inside and outside cells an environment exists which is closely checked by the immune system. A deprivation of ATP in cells leads to necrosis with cell death in a short time (app. 8 min in neurons). A disturbance like membrane depolarization leads to the ignition of the apoptotic pathway. Necrosis and apoptosis show fundamental differences in cellular metabolism 1. Whereas in necrosis the metabolism comes to a total hold...

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    Competing Interests: None declared.