Research ArticleRheumatoid Arthritis

Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis

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Science Translational Medicine  08 Aug 2012:
Vol. 4, Issue 146, pp. 146ra108
DOI: 10.1126/scitranslmed.3003717

Article Information

vol. 4 no. 146 146ra108

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 17, 2012
  • Accepted for publication May 14, 2012

Author Information

  1. Ulrich Flögel1,
  2. Sandra Burghoff1,
  3. Peter L. E. M. van Lent2,
  4. Sebastian Temme1,
  5. Lisa Galbarz1,
  6. Zhaoping Ding1,
  7. Ali El-Tayeb3,*,
  8. Sandra Huels1,
  9. Florian Bönner1,
  10. Nadine Borg1,
  11. Christoph Jacoby1,
  12. Christa E. Müller3,
  13. Wim B. van den Berg2 and
  14. Jürgen Schrader1,
  1. 1Department of Molecular Cardiology, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany.
  2. 2Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen 6525, Netherlands.
  3. 3PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, Bonn 53121, Germany.
  1. To whom correspondence should be addressed. E-mail: schrader{at}uni-duesseldorf.de
  • * On leave from the University of Al-Azhar, Assiut, Egypt.

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