01 August 2012
Vol 4, Issue 145

About The Cover

Cover image expansion

ONLINE COVER Janus Faces of β-Amyloid. Proteins are often poised for polar roles, with Janus-like functions causing damage in some contexts and providing benefit and protection in others. In this week's issue of Science Translational Medicine, Grant et al. have discovered an unexpected protective function of β-amyloid (Aβ) 40 and Aβ42 peptides in experimental autoimmune encephalomyelitis, which is considered an animal model of multiple sclerosis. The anti-inflammatory role of Aβ described here contrasts with the presumed role of Aβ in Alzheimer's disease, where Aβ is thought to play a pathogenic and proinflammatory role of Aβ and is a central target for experimental therapy. These findings provide new strategies for studying the context-dependent functions of Aβ in various neuropathological and inflammatory conditions. [CREDIT: JACQUELINE LEIGH GRANT AND RYAN KATKOV/STANFORD UNIVERSITY; C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]