Research ArticleLaminopathies

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C–Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

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Science Translational Medicine  25 Jul 2012:
Vol. 4, Issue 144, pp. 144ra103
DOI: 10.1126/scitranslmed.3003802

Article Information

vol. 4 no. 144 144ra103

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 1, 2012
  • Accepted for publication July 6, 2012

Author Information

  1. Fresnida J. Ramos1,
  2. Steven C. Chen2,
  3. Michael G. Garelick2,
  4. Dao-Fu Dai1,
  5. Chen-Yu Liao3,
  6. Katherine H. Schreiber3,
  7. Vivian L. MacKay2,
  8. Elroy H. An1,
  9. Randy Strong4,5,6,
  10. Warren C. Ladiges7,
  11. Peter S. Rabinovitch1,
  12. Matt Kaeberlein1,* and
  13. Brian K. Kennedy2,3,*
  1. 1Department of Pathology, University of Washington, Seattle, WA 98195, USA.
  2. 2Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  3. 3Buck Institute for Research on Aging, Novato, CA 94945, USA.
  4. 4The Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA.
  5. 5Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
  6. 6Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, TX 78284, USA.
  7. 7Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.
  1. *To whom correspondence should be addressed. E-mail: bkennedy{at}buckinstitute.org (B.K.K.); kaeber{at}uw.edu (M.K.)

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