Research ArticleHuntington’s Disease

PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

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Science Translational Medicine  11 Jul 2012:
Vol. 4, Issue 142, pp. 142ra97
DOI: 10.1126/scitranslmed.3003799

Article Information

vol. 4 no. 142 142ra97

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 31, 2012
  • Accepted for publication June 22, 2012
  • .

Author Information

  1. Taiji Tsunemi1,
  2. Travis D. Ashe1,
  3. Bradley E. Morrison1,
  4. Kathryn R. Soriano2,
  5. Jonathan Au2,
  6. Ruben A. Vázquez Roque3,
  7. Eduardo R. Lazarowski4,
  8. Vincent A. Damian2,
  9. Eliezer Masliah3,5 and
  10. Albert R. La Spada1,5,6,7,8,9,10,*
  1. 1Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
  2. 2Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
  3. 3Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
  4. 4Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
  5. 5Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
  6. 6Department of Cellular and Molecular Medicine, University of California, San Diego; La Jolla, CA 92093, USA.
  7. 7Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
  8. 8Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  9. 9Rady Children’s Hospital, San Diego, CA 92123, USA.
  10. 10Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
  1. *To whom correspondence should be addressed. E-mail: alaspada{at}ucsd.edu

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