Contents
Vol 4, Issue 142
Contents
Focus
- Got a Light? Illuminating Lung Cancer
New mouse models shed light on mechanisms of lung cancer progression and pinpoint a potential therapeutic target.
Research Articles
- Reproducible Quantification of Cancer-Associated Proteins in Body Fluids Using Targeted Proteomics
A compendium of SRM assays for cancer-associated proteins provides a resource for accelerating and planning biomarker verification studies.
- Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression
Rac1b mediates the matrix metalloproteinase–induced epithelial-mesenchymal transition in lung adenocarcinoma and is a potential therapeutic target in early-stage lung cancer.
- High-Resolution Definition of Vaccine-Elicited B Cell Responses Against the HIV Primary Receptor Binding Site
Vaccine-elicited mAbs bind the HIV-1 Env CD4bs differently from broadly neutralizing infection-induced mAbs.
- PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function
PGC-1α rescues Huntington’s disease neurodegeneration by reducing reactive oxygen species and inducing a master regulator of autophagy.
Review
- Deep Brain Stimulation for Psychiatric Disease: Contributions and Validity of Animal Models
Investigations in animal models can help to understand and improve deep brain stimulation treatments for neuropsychiatric disease.
Editors' Choice
- Focusing In on Virus Inactivation
A new virus inactivation strategy that retains immunogenicity may improve vaccine development.
- Appreciating Staph Support
Staphlyococcus aureus synthesizes two related peptides with divergent functions as an antimicrobial agent and a biofilm-promoting scaffold.
- Getting to the Root of SLOS
Smith-Lemli-Opitz syndrome is associated with increased oxidative stress and lipid peroxidation.
- Too Much of a Good Thing: Hyperoxia and Lung Injury
High oxygen levels during mechanical ventilation can lead to significant lung injury via alterations in alveolar cell structure and function.
- Hair Growth in Action
Real-time imaging in vivo reveals cellular mechanisms of hair growth.
