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Research ArticleParkinson’s Disease
Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s Disease
- Oliver Cooper1,*,†,
- Hyemyung Seo1,*,†‡,
- Shaida Andrabi2,†,
- Cristina Guardia-Laguarta3,†,
- John Graziotto4,†,
- Maria Sundberg1,†,
- Jesse R. McLean1,†,
- Luis Carrillo-Reid5,†,
- Zhong Xie5,†,
- Teresia Osborn1,†,
- Gunnar Hargus1,†,
- Michela Deleidi1,†,
- Tristan Lawson1,†,
- Helle Bogetofte1,†,
- Eduardo Perez-Torres1,†,
- Lorraine Clark3,†,
- Carol Moskowitz3,†,
- Joseph Mazzulli4,†,
- Li Chen2,†,
- Laura Volpicelli-Daley6,†,
- Norma Romero3,†,
- Houbo Jiang7,†,
- Ryan J. Uitti8,†,
- Zhigao Huang9,
- Grzegorz Opala10,
- Leslie A. Scarffe2,†,
- Valina L. Dawson2,†,
- Christine Klein11,
- Jian Feng7,†,
- Owen A. Ross8,†,
- John Q. Trojanowski6,†,
- Virginia M.-Y. Lee6,†,
- Karen Marder3,†,
- D. James Surmeier5,†,
- Zbigniew K. Wszolek8,†,
- Serge Przedborski3,†,
- Dimitri Krainc4,†,
- Ted M. Dawson2,† and
- Ole Isacson1,†§
- 1Neuroregeneration Institute, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA.
- 2Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, and Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- 3Departments of Neurology, Psychiatry, and Pathology and Cell Biology, Sergievsky Center, Taub Institute and the Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA.
- 4MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
- 5Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
- 6Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
- 7Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14214, USA.
- 8Departments of Neurology and Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
- 9University of Florida Shands, Jacksonville, FL 32209, USA.
- 10Department of Neurology, Medical University of Silesia, Katowice 40-055, Poland.
- 11Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck, 23562 Luebeck, Germany.
- ↵§To whom correspondence should be addressed. E-mail: isacson{at}hms.harvard.edu
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Science Translational Medicine 04 Jul 2012:
Vol. 4, Issue 141, pp. 141ra90
DOI: 10.1126/scitranslmed.3003985
Vol. 4, Issue 141, pp. 141ra90
DOI: 10.1126/scitranslmed.3003985
Oliver Cooper
Hyemyung Seo
Shaida Andrabi
Cristina Guardia-Laguarta
John Graziotto
Maria Sundberg
Jesse R. McLean
Luis Carrillo-Reid
Zhong Xie
Teresia Osborn
Gunnar Hargus
Michela Deleidi
Tristan Lawson
Helle Bogetofte
Eduardo Perez-Torres
Lorraine Clark
Carol Moskowitz
Joseph Mazzulli
Li Chen
Laura Volpicelli-Daley
Norma Romero
Houbo Jiang
Ryan J. Uitti
Zhigao Huang
Grzegorz Opala
Leslie A. Scarffe
Valina L. Dawson
Christine Klein
Jian Feng
Owen A. Ross
John Q. Trojanowski
Virginia M.-Y. Lee
Karen Marder
D. James Surmeier
Zbigniew K. Wszolek
Serge Przedborski
Dimitri Krainc
Ted M. Dawson
Ole Isacson
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