Contents
Vol 4, Issue 141
Contents
Commentary
- From Free to Free Market: Cost Recovery in Federally Funded Clinical Research
Hybrid academic-business models are evolving in CTSA clinical research units.
Perspective
- Circulating Tumor Cells: Getting More from Less
Continued technologic innovation may soon permit the interrogation of rare circulating tumor cells to understand tumor biology, guide drug development, and personalize treatment for cancer patients.
Research Articles
- Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s Disease
Neural cells derived from induced pluripotent stem cells from patients with genetic forms of Parkinson’s disease provide insights into disease pathogenesis.
- Targeted Expression of Mutated ALK Induces Neuroblastoma in Transgenic Mice
ALK inhibitors induce complete tumor regression in a mouse model of ALK-driven neuroblastoma.
- Ultrasensitive Clinical Enumeration of Rare Cells ex Vivo Using a Micro-Hall Detector
A hybrid microfluidic/semiconductor chip analyzes single, immunomagnetically tagged ovarian cancer cells in unprocessed biological samples.
- A Tissue Engineering Solution for Segmental Defect Regeneration in Load-Bearing Long Bones
A polycaprolactone-tricalcium phosphate scaffold with recombinant human BMP-7 heals critical-sized bone defects in sheep.
Editors' Choice
- Antibodies Stop Secretion of Antibodies in Lupus
Serum from patients with lupus induces development of dendritic cells that promote B cell responses, including autoantibody secretion.
- You Are What and When You Eat
Time-restricted feeding without reducing caloric intake prevents metabolic disease in mice fed a high-fat diet.
- Getting the Yin Without the Yang with Antiplatelet Therapy
A PAR1 pepducin inhibitor prevents arterial thrombosis, but not coagulation, during coronary interventions.
- Microbiota and Immune Cells: Friends with Benefits
Host-microbial mutualism between gut immune cells and species-specific microbes has developed in mammals and is essential for normal gut immunity.
