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Engineering a Prostate-Specific Membrane Antigen–Activated Tumor Endothelial Cell Prodrug for Cancer Therapy

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Science Translational Medicine  27 Jun 2012:
Vol. 4, Issue 140, pp. 140ra86
DOI: 10.1126/scitranslmed.3003886

Article Information

vol. 4 no. 140 140ra86

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 6, 2012
  • Accepted for publication April 30, 2012
  • .

Author Information

  1. Samuel R. Denmeade1,*,
  2. Annastasiah M. Mhaka1,
  3. D. Marc Rosen1,
  4. W. Nathaniel Brennen1,
  5. Susan Dalrymple1,
  6. Ingrid Dach2,
  7. Claus Olesen2,
  8. Bora Gurel1,
  9. Angelo M. DeMarzo1,
  10. George Wilding3,
  11. Michael A. Carducci1,
  12. Craig A. Dionne4,
  13. Jesper V. Møller2,5,
  14. Poul Nissen2,6,
  15. S. Brøgger Christensen7 and
  16. John T. Isaacs1,*
  1. 1The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
  2. 2Centre for Membrane Pumps in Cells and Disease (PUMPKIN), Danish National Research Foundation, DK-8000 Aarhus, Denmark.
  3. 3University of Wisconsin, Madison, WI 52792, USA.
  4. 4GenSpera Inc., San Antonio, TX 78258, USA.
  5. 5Institute of Physiology and Biophysics, Aarhus University, DK-8000 Aarhus, Denmark.
  6. 6Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.
  7. 7Department of Medicinal Chemistry, University of Copenhagen, DK-2100 Copenhagen, Denmark.
  1. *To whom correspondence should be addressed. E-mail: denmesa{at}jhmi.edu (S.R.D.); isaacjo{at}jhmi.edu (J.T.I.)

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