Contents

Contents

• Focus

  • Boosting Oxygenation During Acute Respiratory Failure

    By Raymond C. Koehler

    Science Translational Medicine27 Jun 2012 : 140fs21 Full AccessRestricted Access

    A new microparticle-based oxygen-delivery technology has been developed for short-term resuscitation of pulmonary function (Kheir et al., this issue).

    • Abstract
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• Research Articles

  • Engineering a Prostate-Specific Membrane Antigen–Activated Tumor Endothelial Cell Prodrug for Cancer Therapy

    By Samuel R. Denmeade, Annastasiah M. Mhaka, D. Marc Rosen, W. Nathaniel Brennen, Susan Dalrymple, Ingrid Dach, Claus Olesen, Bora Gurel, Angelo M. DeMarzo, George Wilding, Michael A. Carducci, Craig A. Dionne, Jesper V. Møller, Poul Nissen, S. Brøgger Christensen, John T. Isaacs

    Science Translational Medicine27 Jun 2012 : 140ra86 Full AccessRestricted Access

    A prostate-specific membrane antigen–activated prodrug selectively kills cancer cells and is being tested in patients with advanced cancer.

    • Editor's Summary
    • Abstract
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  • AAV-Directed Persistent Expression of a Gene Encoding Anti-Nicotine Antibody for Smoking Cessation

    By Martin J. Hicks, Jonathan B. Rosenberg, Bishnu P. De, Odelya E. Pagovich, Colin N. Young, Jian-ping Qiu, Stephen M. Kaminsky, Neil R. Hackett, Stefan Worgall, Kim D. Janda, Robin L. Davisson, Ronald G. Crystal

    Science Translational Medicine27 Jun 2012 : 140ra87 Full AccessRestricted Access

    Gene therapy with an anti-nicotine monoclonal antibody limits nicotine access to the brain in mice and may be a potential therapy for cigarette addiction.

    • Editor's Summary
    • Abstract
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  • Oxygen Gas–Filled Microparticles Provide Intravenous Oxygen Delivery

    By John N. Kheir, Laurie A. Scharp, Mark A. Borden, Edward J. Swanson, Andrew Loxley, James H. Reese, Katherine J. Black, Luis A. Velazquez, Lindsay M. Thomson, Brian K. Walsh, Kathryn E. Mullen, Dionne A. Graham, Michael W. Lawlor, Carlo Brugnara, David C. Bell, Francis X. McGowan, Jr.

    Science Translational Medicine27 Jun 2012 : 140ra88 Full AccessRestricted Access

    A foam suspension containing oxygen gas–filled microparticles can deliver life-sustaining oxygen during a 15-min period of complete asphyxia.

    • Editor's Summary
    • Abstract
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  • Transplantation of Genetically Corrected Human iPSC-Derived Progenitors in Mice with Limb-Girdle Muscular Dystrophy

    By Francesco Saverio Tedesco, Mattia F. M. Gerli, Laura Perani, Sara Benedetti, Federica Ungaro, Marco Cassano, Stefania Antonini, Enrico Tagliafico, Valentina Artusi, Emanuela Longa, Rossana Tonlorenzi, Martina Ragazzi, Giorgia Calderazzi, Hidetoshi Hoshiya, Ornella Cappellari, Marina Mora, Benedikt Schoser, Peter Schneiderat, Mitsuo Oshimura, Roberto Bottinelli, Maurilio Sampaolesi, Yvan Torrente, Vania Broccoli, Giulio Cossu

    Science Translational Medicine27 Jun 2012 : 140ra89 Full AccessRestricted Access

    Genetically corrected mesoangioblasts from human iPSCs derived from limb-girdle muscular dystrophy patients produce muscle fibers expressing the therapeutic gene in a mouse model of the disease.

    • Editor's Summary
    • Abstract
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• State of the Art Review

  • Fresh Approaches to Anti-Infective Therapies

    By Carl Nathan

    Science Translational Medicine27 Jun 2012 : 140sr2 Full AccessRestricted Access

    Characterization of resistant pathogens, new government policies, and creative discovery efforts are needed to maintain an effective antibacterial arsenal.

    • Editor's Summary
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• Editors' Choice

  • A New Trick of the Light: Saving the Heart from Ischemia

    By Aaron B. Baker

    Science Translational Medicine27 Jun 2012 : 140ec111 Full AccessRestricted Access

    Exposure to intense light may be able to reduce the damage from heart attacks.

    • Full Text

  • The ART of Movers and Shakers

    By Ruanne V. Barnabas

    Science Translational Medicine27 Jun 2012 : 140ec112 Full AccessRestricted Access

    Health care that meets the needs of a mobile population has both individual and community benefits for HIV treatment and prevention.

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  • MicroRNAs, a Macro Target in Epilepsy?

    By Chetan Bettegowda

    Science Translational Medicine27 Jun 2012 : 140ec113 Full AccessRestricted Access

    Blocking a key microRNA decreases seizure frequency and reduces brain damage in a mouse model of epilepsy.

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  • From One Stem Cell to Another

    By Carolyn S. Calfee

    Science Translational Medicine27 Jun 2012 : 140ec114 Full AccessRestricted Access

    Mesenchymal stem cells activate endogenous lung stem cells in a mouse model of a chronic lung disease of prematurity.

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