Contents
Vol 4, Issue 140
Contents
Focus
- Boosting Oxygenation During Acute Respiratory Failure
A new microparticle-based oxygen-delivery technology has been developed for short-term resuscitation of pulmonary function (Kheir et al., this issue).
Research Articles
- Engineering a Prostate-Specific Membrane Antigen–Activated Tumor Endothelial Cell Prodrug for Cancer Therapy
A prostate-specific membrane antigen–activated prodrug selectively kills cancer cells and is being tested in patients with advanced cancer.
- AAV-Directed Persistent Expression of a Gene Encoding Anti-Nicotine Antibody for Smoking Cessation
Gene therapy with an anti-nicotine monoclonal antibody limits nicotine access to the brain in mice and may be a potential therapy for cigarette addiction.
- Oxygen Gas–Filled Microparticles Provide Intravenous Oxygen Delivery
A foam suspension containing oxygen gas–filled microparticles can deliver life-sustaining oxygen during a 15-min period of complete asphyxia.
- Transplantation of Genetically Corrected Human iPSC-Derived Progenitors in Mice with Limb-Girdle Muscular Dystrophy
Genetically corrected mesoangioblasts from human iPSCs derived from limb-girdle muscular dystrophy patients produce muscle fibers expressing the therapeutic gene in a mouse model of the disease.
State of the Art Review
- Fresh Approaches to Anti-Infective Therapies
Characterization of resistant pathogens, new government policies, and creative discovery efforts are needed to maintain an effective antibacterial arsenal.
Editors' Choice
- A New Trick of the Light: Saving the Heart from Ischemia
Exposure to intense light may be able to reduce the damage from heart attacks.
- The ART of Movers and Shakers
Health care that meets the needs of a mobile population has both individual and community benefits for HIV treatment and prevention.
- MicroRNAs, a Macro Target in Epilepsy?
Blocking a key microRNA decreases seizure frequency and reduces brain damage in a mouse model of epilepsy.
- From One Stem Cell to Another
Mesenchymal stem cells activate endogenous lung stem cells in a mouse model of a chronic lung disease of prematurity.