Research ArticleHepatocellular carcinoma

mTOR Inhibitors Synergize on Regression, Reversal of Gene Expression, and Autophagy in Hepatocellular Carcinoma

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Science Translational Medicine  20 Jun 2012:
Vol. 4, Issue 139, pp. 139ra84
DOI: 10.1126/scitranslmed.3003923

Article Information

vol. 4 no. 139 139ra84

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 22, 2012
  • Accepted for publication April 10, 2012
  • .

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Author Information

  1. Hala Elnakat Thomas1,2,
  2. Carol A. Mercer2,
  3. Larissa S. Carnevalli1,*,
  4. Jongsun Park1,2,,
  5. Jesper B. Andersen3,
  6. Elizabeth A. Conner3,
  7. Kazuhiro Tanaka4,
  8. Tomoo Matsutani4,
  9. Akio Iwanami4,
  10. Bruce J. Aronow5,
  11. Liu Manway6,
  12. S. Michel Maira7,
  13. Snorri S. Thorgeirsson3,
  14. Paul S. Mischel4,
  15. George Thomas1,2,8 and
  16. Sara C. Kozma1,2,8,
  1. 1Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH 45215, USA.
  2. 2Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH 45215, USA.
  3. 3Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  4. 4Departments of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  5. 5Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.
  6. 6Novartis Institutes for Biomedical Research Inc., Cambridge, MA 02139, USA.
  7. 7Novartis Institutes for Biomedical Research Inc., CH-4002 Basel, Switzerland.
  8. 8Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona 08908, Spain.
  1. To whom correspondence should be addressed. E-mail: sara.kozma{at}uc.edu
  • * Present address: Heidelberg Institute for Stem Cell Technology and Experimental Medicine, D-69120 Heidelberg, Germany.

  • Present address: Department of Pharmacology, College of Medicine, Chungnam National University, Taejon 301-131, South Korea.

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