20 June 2012
Vol 4, Issue 139
  • Contents

    • Focus

    • Research Articles

      • DNAzyme Targeting c-jun Suppresses Skin Cancer Growth

        Catalytic DNA molecules that target the transcription factor c-jun inhibit skin cancer growth in mice.

      • The Structural Basis for Serotype-Specific Neutralization of Dengue Virus by a Human Antibody

        The mechanism of action of a serotype-specific natural human antibody against dengue virus has been identified.

      • mTOR Inhibitors Synergize on Regression, Reversal of Gene Expression, and Autophagy in Hepatocellular Carcinoma

        Combination therapy causes gene reprogramming, autophagy, and tumor regression in a mouse model approximating human HCC.

      • Recombinant MG53 Protein Modulates Therapeutic Cell Membrane Repair in Treatment of Muscular Dystrophy

        Recombinant human MG53 protein can increase membrane repair after injury in cells and can reduce pathology in animal models of muscle injury and muscular dystrophy.

    • Editors' Choice

      • Going Deep

        Stimulation of specific brain structures evokes neural plasticity at distant sites, explaining how deep brain stimulation may help patients with obsessive-compulsive disorder.

      • Not Enough Myocytes? Use Fibroblasts!

        Reprogramming cardiac fibroblasts to a myocyte fate improves heart function after myocardial infarction in mice.

About The Cover

Cover image expansion

ONLINE COVER Mending Muscle. In Duchenne muscular dystrophy (DMD), muscle cells are unable to repair damaged plasma membranes, ultimately resulting in weakened muscle and patient fatigue. There is no cure for DMD. However, Weisleder and colleagues have now discovered that treatment with a muscle repair protein, MG53, can help reseal the membrane and restore muscle function in mice with the disease. In this image, fluorescently labeled MG53 rushes to the site of damage to reseal a muscle myotube's plasma membrane. See related Focus by Burkin. [CREDIT: N.WEISLEDER/UMDNJ-ROBERT WOOD JOHNSON MEDICAL SCHOOL]