Contents
Vol 4, Issue 138
Contents
Editorial
- Listen, Understand, Engage
For more effective vaccine advocacy, scientists and policy-makers must translate and apply insights from the cognitive and social sciences to the way they communicate and engage with the public.
Focus
- The Virus That Came In from the Cold
A common-cold virus uses an undercover strategy to avoid neutralizing antibodies in cancer patients and targets distant sites of metastatic cancer growth.
- Autoimmune Diabetes Inflames the Heart
Patients with type 1 diabetes tend to suffer subsequent and persistent inflammation of cardiac tissue after a heart attack.
Research Articles
- Cell Carriage, Delivery, and Selective Replication of an Oncolytic Virus in Tumor in Patients
Oncolytic reovirus is carried by cells to tumors and protected from neutralizing antibodies in the circulation.
- Exome Sequencing Can Improve Diagnosis and Alter Patient Management
Exome sequencing of 118 patients with neurodevelopmental disorders shows that this technique is useful for identifying new pathogenic mutations and for correcting diagnosis in ~10% of cases.
- Mucus-Penetrating Nanoparticles for Vaginal Drug Delivery Protect Against Herpes Simplex Virus
Mucus-penetrating particles improve drug delivery to the mucosal surface of the mouse vagina and deliver acyclovir for enhanced protection against vaginal herpes infection in mice.
- Myocardial Infarction Triggers Chronic Cardiac Autoimmunity in Type 1 Diabetes
Acute myocardial infarction triggers an autoimmune attack on the heart in a mouse model of type 1 diabetes and in human type 1 diabetic patients.
- Successful Treatment of Ebola Virus–Infected Cynomolgus Macaques with Monoclonal Antibodies
Macaques survived infection with Ebola virus when treated starting at 24 hours after infection with mix of three neutralizing monoclonal antibodies.
Editors' Choice
- Blocking an Immune Inhibitor: Small Step or Giant Leap?
Cancer patients with an array of ligand-positive tumors can be treated safely with an antibody that blocks an inhibitory immune receptor.
- You Can Run, But You Can’t Hide
A humanized model provides a new way to study the bone marrow niches where some malignant cells “hide” during chemotherapy.
- Seeing an Earful
A noninvasive imaging method can detect bacterial infections in the middle ear.
- May the Resolvins Be with You…
Mediators that resolve acute inflammation reduce the requirement for antibiotics.
- The Inflammasome Pathway: A Formidable Foe in Critically Ill Patients
The inflammasome pathway and its product interleukin-18 play a critical role in acute lung injury, a common complication in ICU patients.
Erratum
