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A Validated Tumorgraft Model Reveals Activity of Dovitinib Against Renal Cell Carcinoma

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Science Translational Medicine  06 Jun 2012:
Vol. 4, Issue 137, pp. 137ra75
DOI: 10.1126/scitranslmed.3003643

Article Information

vol. 4 no. 137 137ra75

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 22, 2011
  • Accepted for publication April 10, 2012

Author Information

  1. Sharanya Sivanand1,2,3,
  2. Samuel Peña-Llopis1,2,3,
  3. Hong Zhao3,
  4. Blanka Kucejova1,2,3,
  5. Patrick Spence1,2,3,
  6. Andrea Pavia-Jimenez1,2,3,
  7. Toshinari Yamasaki1,2,3,
  8. David J. McBride4,
  9. Jessica Gillen1,2,3,
  10. Nicholas C. Wolff1,2,3,
  11. Lorraine Morlock5,
  12. Yair Lotan6,
  13. Ganesh V. Raj6,
  14. Arthur Sagalowsky6,
  15. Vitaly Margulis6,
  16. Jeffrey A. Cadeddu6,
  17. Mark T. Ross4,
  18. David R. Bentley4,
  19. Wareef Kabbani7,
  20. Xian-Jin Xie3,
  21. Payal Kapur7,
  22. Noelle S. Williams5 and
  23. James Brugarolas1,2,3,*
  1. 1Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  2. 2Department of Internal Medicine, Oncology Division, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  3. 3Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  4. 4Illumina Cambridge Ltd., Chesterford Research Park, Little Chesterford, Essex CB10 1XL, UK.
  5. 5Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  6. 6Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  7. 7Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  1. *To whom correspondence should be addressed. E-mail: james.brugarolas{at}utsouthwestern.edu

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