Contents

Contents

• Perspective

  • The Human Gut Microbiota and Undernutrition

    By Jeffrey I. Gordon, Kathryn G. Dewey, David A. Mills, Ruslan M. Medzhitov

    Science Translational Medicine06 Jun 2012 : 137ps12 Full AccessRestricted Access

    Elucidating the relationship between breast milk and the developing infant gut microbiota and immune system will provide new insights into malnutrition.

    • Abstract
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• Research Articles

  • Preexisting BCG-Specific T Cells Improve Intravesical Immunotherapy for Bladder Cancer

    By Claire Biot, Cyrill A. Rentsch, Joel R. Gsponer, Frédéric D. Birkhäuser, Hélène Jusforgues-Saklani, Fabrice Lemaître, Charlotte Auriau, Alexander Bachmann, Philippe Bousso, Caroline Demangel, Lucie Peduto, George N. Thalmann, Matthew L. Albert

    Science Translational Medicine06 Jun 2012 : 137ra72 Full AccessRestricted Access

    Preexisting immunity to BCG improves treatment response to intravesical BCG therapy for bladder cancer in mouse models and humans.

    • Editor's Summary
    • Abstract
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  • Identification of Naturally Occurring Fatty Acids of the Myelin Sheath That Resolve Neuroinflammation

    By Peggy P. Ho, Jennifer L. Kanter, Amanda M. Johnson, Hrishikesh K. Srinagesh, Eun-Ju Chang, Timothy M. Purdy, Keith van Haren, William R. Wikoff, Tobias Kind, Mohsen Khademi, Laura Y. Matloff, Sirisha Narayana, Eun Mi Hur, Tamsin M. Lindstrom, Zhigang He, Oliver Fiehn, Tomas Olsson, Xianlin Han, May H. Han, Lawrence Steinman, William H. Robinson

    Science Translational Medicine06 Jun 2012 : 137ra73 Full AccessRestricted Access

    Myelin fatty acids resolve neuroinflammation.

    • Editor's Summary
    • Abstract
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  • Phase 1 Study of Stereotactic Body Radiotherapy and Interleukin-2—Tumor and Immunological Responses

    By Steven K. Seung, Brendan D. Curti, Marka Crittenden, Edwin Walker, Todd Coffey, Janet C. Siebert, William Miller, Roxanne Payne, Lyn Glenn, Alexandru Bageac, Walter J. Urba

    Science Translational Medicine06 Jun 2012 : 137ra74 Full AccessRestricted Access

    Stereotactic body radiation therapy enhances tumor response rate to high-dose interleukin-2 in a phase 1 study.

    • Editor's Summary
    • Abstract
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  • A Validated Tumorgraft Model Reveals Activity of Dovitinib Against Renal Cell Carcinoma

    By Sharanya Sivanand, Samuel Peña-Llopis, Hong Zhao, Blanka Kucejova, Patrick Spence, Andrea Pavia-Jimenez, Toshinari Yamasaki, David J. McBride, Jessica Gillen, Nicholas C. Wolff, Lorraine Morlock, Yair Lotan, Ganesh V. Raj, Arthur Sagalowsky, Vitaly Margulis, Jeffrey A. Cadeddu, Mark T. Ross, David R. Bentley, Wareef Kabbani, Xian-Jin Xie, Payal Kapur, Noelle S. Williams, James Brugarolas

    Science Translational Medicine06 Jun 2012 : 137ra75 Full AccessRestricted Access

    Extensively validated tumorgraft model shows activity of investigational agent dovitinib against renal cell carcinoma.

    • Editor's Summary
    • Abstract
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  • Noninvasive Whole-Genome Sequencing of a Human Fetus

    By Jacob O. Kitzman, Matthew W. Snyder, Mario Ventura, Alexandra P. Lewis, Ruolan Qiu, LaVone E. Simmons, Hilary S. Gammill, Craig E. Rubens, Donna A. Santillan, Jeffrey C. Murray, Holly K. Tabor, Michael J. Bamshad, Evan E. Eichler, Jay Shendure

    Science Translational Medicine06 Jun 2012 : 137ra76 Full AccessRestricted Access

    Sequencing of cell-free fetal-derived DNA from maternal plasma provides a noninvasive way to predict the fetal genome sequence.

    • Editor's Summary
    • Abstract
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• Reviews

  • Microbiota-Targeted Therapies: An Ecological Perspective

    By Katherine P. Lemon, Gary C. Armitage, David A. Relman, Michael A. Fischbach

    Science Translational Medicine06 Jun 2012 : 137rv5 Full AccessRestricted Access

    Insights from ecology will help to drive the development of microbiota-targeted therapeutics.

    • Abstract
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  • Therapeutic Modulation of Microbiota-Host Metabolic Interactions

    By Elaine Holmes, James Kinross, Glenn R. Gibson, Remy Burcelin, Wei Jia, Sven Pettersson, Jeremy K. Nicholson

    Science Translational Medicine06 Jun 2012 : 137rv6 Full AccessRestricted Access

    Abnormal microbial-host metabolic interactions underlying disease provide new targets for therapeutic intervention.

    • Abstract
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  • Microbiota, Disease, and Back to Health: A Metastable Journey

    By Richard Blumberg, Fiona Powrie

    Science Translational Medicine06 Jun 2012 : 137rv7 Full AccessRestricted Access

    The gut microbiota affects many immune-related diseases; the next step is to harness this knowledge for therapeutics.

    • Abstract
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• Editors' Choice

  • Help—Plumber Needed

    By Heiko Methe

    Science Translational Medicine06 Jun 2012 : 137ec98 Full AccessRestricted Access

    A cyclic peptide breaks up clogs in the kidneys of patients with multiple myeloma.

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  • Meds Disturb Motor Development

    By Manpreet K. Singh

    Science Translational Medicine06 Jun 2012 : 137ec99 Full AccessRestricted Access

    Intrauterine exposure to antipsychotic medication can decrease motor skills in infants.

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  • Casting a Wide NET for TRALI

    By Yvette Tanhehco

    Science Translational Medicine06 Jun 2012 : 137ec100 Full AccessRestricted Access

    Neutrophil extracellular traps formed during lung injury contribute to disease development and provide targets for specific therapy.

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  • Immunity Is But Skin Deep: Context Is Everything

    By Bryan G. Yipp

    Science Translational Medicine06 Jun 2012 : 137ec101 Full AccessRestricted Access

    Epidermal Langerhans cells dictate specific immune responses of the skin resident memory T lymphocyte population in humans.

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