Contents
Vol 4, Issue 137
Contents
Perspective
- The Human Gut Microbiota and Undernutrition
Elucidating the relationship between breast milk and the developing infant gut microbiota and immune system will provide new insights into malnutrition.
Research Articles
- Preexisting BCG-Specific T Cells Improve Intravesical Immunotherapy for Bladder Cancer
Preexisting immunity to BCG improves treatment response to intravesical BCG therapy for bladder cancer in mouse models and humans.
- Identification of Naturally Occurring Fatty Acids of the Myelin Sheath That Resolve Neuroinflammation
Myelin fatty acids resolve neuroinflammation.
- Phase 1 Study of Stereotactic Body Radiotherapy and Interleukin-2—Tumor and Immunological Responses
Stereotactic body radiation therapy enhances tumor response rate to high-dose interleukin-2 in a phase 1 study.
- A Validated Tumorgraft Model Reveals Activity of Dovitinib Against Renal Cell Carcinoma
Extensively validated tumorgraft model shows activity of investigational agent dovitinib against renal cell carcinoma.
- Noninvasive Whole-Genome Sequencing of a Human Fetus
Sequencing of cell-free fetal-derived DNA from maternal plasma provides a noninvasive way to predict the fetal genome sequence.
Reviews
- Microbiota-Targeted Therapies: An Ecological Perspective
Insights from ecology will help to drive the development of microbiota-targeted therapeutics.
- Therapeutic Modulation of Microbiota-Host Metabolic Interactions
Abnormal microbial-host metabolic interactions underlying disease provide new targets for therapeutic intervention.
- Microbiota, Disease, and Back to Health: A Metastable Journey
The gut microbiota affects many immune-related diseases; the next step is to harness this knowledge for therapeutics.
Editors' Choice
- Help—Plumber Needed
A cyclic peptide breaks up clogs in the kidneys of patients with multiple myeloma.
- Meds Disturb Motor Development
Intrauterine exposure to antipsychotic medication can decrease motor skills in infants.
- Casting a Wide NET for TRALI
Neutrophil extracellular traps formed during lung injury contribute to disease development and provide targets for specific therapy.
- Immunity Is But Skin Deep: Context Is Everything
Epidermal Langerhans cells dictate specific immune responses of the skin resident memory T lymphocyte population in humans.