Research ArticleCancer Genomics

Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA

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Science Translational Medicine  30 May 2012:
Vol. 4, Issue 136, pp. 136ra68
DOI: 10.1126/scitranslmed.3003726

Article Information

vol. 4 no. 136 136ra68

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History: 
  • Received for publication October 24, 2011
  • Accepted for publication April 18, 2012
  • .

Author Information

  1. Tim Forshew1,*,
  2. Muhammed Murtaza1,2,*,
  3. Christine Parkinson1,2,3,*,
  4. Davina Gale1,*,
  5. Dana W. Y. Tsui1,*,
  6. Fiona Kaper4,,
  7. Sarah-Jane Dawson1,2,3,
  8. Anna M. Piskorz1,2,
  9. Mercedes Jimenez-Linan3,5,
  10. David Bentley6,
  11. James Hadfield1,
  12. Andrew P. May4,
  13. Carlos Caldas1,2,3,7,
  14. James D. Brenton1,2,3,7, and
  15. Nitzan Rosenfeld1,2,
  1. 1Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
  2. 2Department of Oncology, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK.
  3. 3Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK.
  4. 4Fluidigm Corporation, 7000 Shoreline Court, Suite 100, South San Francisco, CA 94080, USA.
  5. 5Department of Histopathology, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK.
  6. 6Illumina Cambridge, Chesterford Research Park, Little Chesterford, Cambridge CB10 1XL, UK.
  7. 7Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK.
  1. To whom correspondence should be addressed. E-mail: nitzan.rosenfeld{at}cancer.org.uk (N.R.); james.brenton{at}cancer.org.uk (J.D.B.)
  • * These authors contributed equally to this work.

  • Present address: Illumina, Inc., 5200 Illumina Way, San Diego, CA 92122, USA.

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