30 May 2012
Vol 4, Issue 136

About The Cover

Cover image expansion

ONLINE COVER Out of One, Many. In a complex process usually triggered by injury, resident tissue cells, invading inflammatory cells, extracellular matrix proteins, and small molecules interact to create a fibrotic network. There are no effective therapies for fibrosis, which can ultimately lead to organ failure. In this issue, Yamaguchi and colleagues identified a small peptide derived from endostatin, named E4, with potent antifibrotic activity. E4 displayed an appropriately multipronged effect for this multifaceted process, by targeting numerous aspects of fibrosis in both skin and lungs. See the accompanying Focus by Atamas. [CREDIT: B. STRAUCH/SCIENCE TRANSLATIONAL MEDICINE]