Contents
Vol 4, Issue 136
Contents
Editorial
- Seeking Validation
Clinical validation of new drug targets may best occur in precompetitive partnerships.
Focus
- Relief from Within: A Peptide Therapy for Fibrosis
A modified natural peptide, E4, has the potential to become a breakthrough therapy for those afflicted with organ fibrosis (Yamaguchi et al., this issue).
Research Articles
- Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA
Sizable genomic regions were screened and low-frequency mutations were identified in circulating DNA of cancer patients using tagged-amplicon deep sequencing (TAm-Seq).
- SIV Replication in the Infected Rhesus Macaque Is Limited by the Size of the Preexisting TH17 Cell Compartment
Macaques with abundant TH17 cells in blood and intestinal tissue before infection are resistant to SIV replication.
- Kinase-Impaired BRAF Mutations in Lung Cancer Confer Sensitivity to Dasatinib
Induction of tumor cell senescence may explain the response of a patient with BRAF kinase–impaired lung cancer to the multikinase inhibitor dasatinib.
- A Peptide Derived from Endostatin Ameliorates Organ Fibrosis
A naturally occurring peptide from endostatin can inhibit fibrosis in lung and skin, even when it is already established.
Editors' Choice
- To Serve and Neuro-Protect
A new drug shows promise for protecting the brain after stroke.
- Bang for Development Bucks
Spending on HIV treatment and care is associated with lower overall mortality rates.
- Pesticides Perturb Prenatal Brain
Prenatal exposure to a common pesticide has been linked to changes in brain structure and function.
- Smog Signals
A natural experiment explores the mechanisms by which air pollution affects cardiovascular health.
- Perceiving Your Appetite
Intranasal insulin suppresses food intake via enhancement of brain energy levels in humans.
