Research ArticleCancer Immunotherapy

CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients

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Science Translational Medicine  16 May 2012:
Vol. 4, Issue 134, pp. 134ra62
DOI: 10.1126/scitranslmed.3003330

Article Information

vol. 4 no. 134 134ra62

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 17, 2011
  • Accepted for publication March 30, 2012
  • .

Author Information

  1. Andrew J. Rech1,*,
  2. Rosemarie Mick2,3,*,
  3. Sunil Martin1,4,*,
  4. Adri Recio1,
  5. Nicole A. Aqui2,5,
  6. Daniel J. Powell Jr.1,2,5,
  7. Theresa A. Colligon1,
  8. Jennifer A. Trosko1,
  9. Leah I. Leinbach5,
  10. Charles H. Pletcher5,
  11. Carol K. Tweed2,6,
  12. Angela DeMichele2,6,
  13. Kevin R. Fox2,6,
  14. Susan M. Domchek2,6,
  15. James L. Riley1,2,4, and
  16. Robert H. Vonderheide1,2,6,
  1. 1Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  2. 2Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  3. 3Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  4. 4Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  5. 5Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  6. 6Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  1. To whom correspondence should be addressed. E-mail: rhv{at}exchange.upenn.edu (R.H.V.); rileyj{at}exchange.upenn.edu (J.L.R.)
  • * These authors contributed equally to this work.

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