Contents
Vol 4, Issue 133
Contents
Focus
- Three Strikes and You’re Cured
Glucose tolerance can be restored in a mouse model of type 1 diabetes be abrogating autoimmunity and then exploiting the ability of pancreatic β cells to regenerate.
- What’s a Genome Worth?
A recent study (Roberts et al.) explores considerations in estimating the current and potential clinical utility of whole-genome sequencing for individual patients.
Research Articles
- Survivin Is a Therapeutic Target in Merkel Cell Carcinoma
A targeted therapy for a virus-induced cancer involves blockade of the cellular oncoprotein survivin.
- Extended Survival of Glioblastoma Patients After Chemoprotective HSC Gene Therapy
Gene therapy using P140K-modified hematopoietic progenitor cells is chemoprotective, enabling glioblastoma patients to withstand myelotoxic doses of chemotherapy.
- The Predictive Capacity of Personal Genome Sequencing
A statistical method applied to monozygotic twin data assesses the ability of whole-genome sequencing to predict disease risk in the general population.
- Mixed Chimerism and Growth Factors Augment β Cell Regeneration and Reverse Late-Stage Type 1 Diabetes
Combination therapy that induces mixed chimerism and augments both β cell neogenesis and replication reverses late-stage type 1 diabetes in NOD mice.
Editors' Choice
- Smoking Gets Ahold of Your Genes
Methylation intensity of F2RL3 is lower in smokers and predicts mortality in patients with coronary heart disease.
- The Brain Says Go!
Specific neural networks are associated with impulse control in teenagers.
- Stressing Out the Endoplasmic Reticulum
Inhibiting the unfolded protein response helps kill multiple myeloma cells.
- The Lymphocyte Subset Club: New Members Welcome
Pathogen-specific TH17 lymphocyte subsets develop unique cytokine profiles to combat different microbial invaders.
