Human Mesenchymal Stem Cell–Derived Matrices for Enhanced Osteoregeneration

Suzanne Zeitouni; Ulf Krause; Bret H. Clough; Hillary Halderman; Alexander Falster; Darryl T. Blalock; Christopher D. Chaput; H. Wayne Sampson; Carl A. Gregory

doi:10.1126/scitranslmed.3003396

Research ArticleBIOMATERIALS

Human Mesenchymal Stem Cell–Derived Matrices for Enhanced Osteoregeneration

Suzanne Zeitouni¹,²,*,
Ulf Krause¹,*,
Bret H. Clough¹,
Hillary Halderman²,
Alexander Falster³,
Darryl T. Blalock¹,
Christopher D. Chaput⁴,
H. Wayne Sampson² and
Carl A. Gregory¹,^†

¹Institute for Regenerative Medicine at Scott and White Hospital, Texas A&M Health Science Center, Module C, 5701 Airport Road, Temple, TX 76502, USA.
²Systems Biology and Translational Medicine, Texas A&M Health Science Center, 701 Southwest H. K. Dodgen Loop, Temple, TX 76504, USA.
³Department of Earth and Environmental Sciences, University of New Orleans, New Orleans, LA 70148, USA.
⁴Department of Orthopedic Surgery, Scott and White Hospital, Texas A&M Health Science Center, 2401 South 31st Street, Temple, TX 76508, USA.

↵†To whom correspondence should be addressed. E-mail: cgregory{at}medicine.tamhsc.edu

↵* These authors contributed equally to this work.

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Science Translational Medicine 02 May 2012:
Vol. 4, Issue 132, pp. 132ra55
DOI: 10.1126/scitranslmed.3003396

Suzanne Zeitouni

1Institute for Regenerative Medicine at Scott and White Hospital, Texas A&M Health Science Center, Module C, 5701 Airport Road, Temple, TX 76502, USA.2Systems Biology and Translational Medicine, Texas A&M Health Science Center, 701 Southwest H. K. Dodgen Loop, Temple, TX 76504, USA.

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Ulf Krause

1Institute for Regenerative Medicine at Scott and White Hospital, Texas A&M Health Science Center, Module C, 5701 Airport Road, Temple, TX 76502, USA.

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Bret H. Clough

1Institute for Regenerative Medicine at Scott and White Hospital, Texas A&M Health Science Center, Module C, 5701 Airport Road, Temple, TX 76502, USA.

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Hillary Halderman

2Systems Biology and Translational Medicine, Texas A&M Health Science Center, 701 Southwest H. K. Dodgen Loop, Temple, TX 76504, USA.

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Alexander Falster

3Department of Earth and Environmental Sciences, University of New Orleans, New Orleans, LA 70148, USA.

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Darryl T. Blalock

1Institute for Regenerative Medicine at Scott and White Hospital, Texas A&M Health Science Center, Module C, 5701 Airport Road, Temple, TX 76502, USA.

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Christopher D. Chaput

4Department of Orthopedic Surgery, Scott and White Hospital, Texas A&M Health Science Center, 2401 South 31st Street, Temple, TX 76508, USA.

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H. Wayne Sampson

2Systems Biology and Translational Medicine, Texas A&M Health Science Center, 701 Southwest H. K. Dodgen Loop, Temple, TX 76504, USA.

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Carl A. Gregory

1Institute for Regenerative Medicine at Scott and White Hospital, Texas A&M Health Science Center, Module C, 5701 Airport Road, Temple, TX 76502, USA.

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For correspondence: cgregory@medicine.tamhsc.edu

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Human Mesenchymal Stem Cell–Derived Matrices for Enhanced Osteoregeneration

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