Research ArticleAutism

Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism

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Science Translational Medicine  25 Apr 2012:
Vol. 4, Issue 131, pp. 131ra51
DOI: 10.1126/scitranslmed.3003501

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  • Autism Symptoms: Disorder or Defense?

    The emerging possibility of reversing neurodevelopmental disorders in children or adults represents one of the most exciting recent developments in psychiatry. Silverman et al. (2012) have made a notable step towards this goal, by showing that pharmacological downregulation of the mGlur5 receptor in two different mouse models of autism diminishes repetitive behavior and increases social interactivity.

    One importa...

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    Competing Interests: None declared.

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