Contents
Vol 4, Issue 131
Contents
Focus
- Tweaking the Social Network
A preclinical mouse model of autism spectrum disorder paves the way for clinical trials with a glutamate receptor antagonist.
- Thoroughly Modern Risk Prediction?
Researchers use a data-driven technique called statistical learning to fashion risk prediction algorithms for clinical situations with low event rates.
Research Articles
- Looking Beyond Historical Patient Outcomes to Improve Clinical Models
Clinical models can be improved by decreasing the importance assigned to fitting historical patient outcomes in often small and imperfectly characterized derivation cohorts.
- Suppression of Phosphoinositide 3-Kinase Signaling and Alteration of Multiple Ion Currents in Drug-Induced Long QT Syndrome
The dangerous heart arrhythmias that are triggered as a side effect of some drugs are caused by many ion channels, prompting a rethinking of how we screen for these adverse events.
- Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism
Autism-like behaviors in mice were reversed by a negative modulator of a metabotropic glutamate receptor, suggesting a treatment for symptoms of autism spectrum disorders.
Editors' Choice
- Separate But Not Equal: Giving the NOD to Innate Immunity in Leprosy
Different leprosy pathogen components drive distinct paths of dendritic cell development from monocytes.
- Carrier and Therapeutic in One
Spherical particles formed of long RNA polymers are taken up by cells and transformed into therapeutic short interfering RNAs.
- Consciousness Reborn
PET scanning while subjects emerge from general anesthesia reveals the neural core of consciousness.
- A Big Step Forward for Tiny Particles
Multimodal nanoparticles guide brain tumor staging and resection in mice.
- iNKT Cells Live Off the Fat of the Land
iNKT cells link obesity-induced inflammation, insulin resistance, and hepatic steatosis.
Letters
- Comment on “A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys”
A study reporting that a peptidomimetic adipotide reduces weight loss in obese monkeys by inducing apoptosis of blood vessels surrounding white adipose tissue may instead reflect a direct effect of adipotide on food consumption.
- Response to Comment on “A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys”
Several lines of evidence indicate that the effects of adipotide on weight loss and food consumption in obese monkeys are not due to a toxic effect, but rather result from the targeting mechanism of adipotide.
