Research ArticleBreast Cancer

Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2+ Breast Cancer Growth and Metastasis

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Science Translational Medicine  18 Apr 2012:
Vol. 4, Issue 130, pp. 130ra48
DOI: 10.1126/scitranslmed.3003601

Article Information

vol. 4 no. 130 130ra48

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 14, 2011
  • Accepted for publication February 22, 2012
  • .

Author Information

  1. Yan-dan Yao1,*,
  2. Tian-meng Sun2,*,
  3. Song-yin Huang1,
  4. Shuang Dou2,
  5. Ling Lin1,
  6. Jia-ning Chen1,
  7. Jian-bin Ruan2,
  8. Cheng-qiong Mao2,
  9. Feng-yan Yu1,
  10. Mu-sheng Zeng3,
  11. Jian-ye Zang2,
  12. Qiang Liu1,
  13. Feng-xi Su1,
  14. Peter Zhang4,
  15. Judy Lieberman5,,
  16. Jun Wang2, and
  17. Erwei Song1,
  1. 1Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
  2. 2Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
  3. 3State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
  4. 4Shanghai GenePharma Co. Ltd., Shanghai 201203, China.
  5. 5Immune Disease Institute and Program in Cellular and Molecular Medicine, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
  1. To whom correspondence should be addressed. E-mail: songerwei02{at}yahoo.com.cn (E.S.); jwang699{at}ustc.edu.cn (J.W.); lieberman{at}idi.harvard.edu (J.L.)
  • * These authors contributed equally to this work.

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