Research ArticleNanomedicine

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

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Science Translational Medicine  04 Apr 2012:
Vol. 4, Issue 128, pp. 128ra39
DOI: 10.1126/scitranslmed.3003651

Article Information

vol. 4 no. 128 128ra39

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 27, 2011
  • Accepted for publication March 16, 2012
  • .

Author Information

  1. Jeffrey Hrkach1,
  2. Daniel Von Hoff2,
  3. Mir Mukkaram Ali1,
  4. Elizaveta Andrianova1,
  5. Jason Auer1,
  6. Tarikh Campbell1,
  7. David De Witt1,
  8. Michael Figa1,
  9. Maria Figueiredo1,
  10. Allen Horhota1,
  11. Susan Low1,
  12. Kevin McDonnell1,
  13. Erick Peeke1,
  14. Beadle Retnarajan1,
  15. Abhimanyu Sabnis1,
  16. Edward Schnipper1,
  17. Jeffrey J. Song1,
  18. Young Ho Song1,
  19. Jason Summa1,
  20. Douglas Tompsett1,
  21. Greg Troiano1,
  22. Tina Van Geen Hoven1,
  23. Jim Wright1,
  24. Patricia LoRusso3,
  25. Philip W. Kantoff4,
  26. Neil H. Bander5,
  27. Christopher Sweeney4,
  28. Omid C. Farokhzad6,*,
  29. Robert Langer7,* and
  30. Stephen Zale1,*
  1. 1BIND Biosciences Inc., Cambridge, MA 02139, USA.
  2. 2TGen Clinical Research Services at Scottsdale Healthcare, Phoenix, AZ 85004, USA.
  3. 3Karmanos Cancer Institute, Detroit, MI 48201, USA.
  4. 4Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
  5. 5Weill Cornell Medical College, New York, NY 10065, USA.
  6. 6Laboratory of Nanomedicine and Biomaterials and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  7. 7Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  1. *To whom correspondence should be addressed. E-mail: ofarokhzad{at}zeus.bwh.harvard.edu (O.C.F.); rlanger{at}mit.edu (R.L.); szale{at}bindbio.com (S.Z.)

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