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ADITEC: Joining Forces for Next-Generation Vaccines

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Science Translational Medicine  04 Apr 2012:
Vol. 4, Issue 128, pp. 128cm4
DOI: 10.1126/scitranslmed.3003826
  • Fig. 1. The ADITEC strategy.

    Shown is a schematic representation of basic concepts of the ADITEC project. Human immunology, studied in the clinic and supported with systems biology tools and investigations, will be used to study the impact of new technologies, including vaccine adjuvants, formulations, and delivery systems. Animal models will be used in parallel to support the study and validation of mechanisms of human immunology.

    CREDIT: Y. HAMMONDSCIENCE TRANSLATIONAL MEDICINE
  • Fig. 2. Immunization technologies.

    Schematic representation of immunization technologies (antigens, adjuvants, and vectors) investigated within ADITEC. Model antigens that have been selected for study are hemoagglutinin from influenza strain H1N1 A/California/09 and the H56 fusion protein, which consists of Ag85B, ESAT6, and Rv2660c from Mycobacterium tuberculosis. Adjuvants studied in ADITEC will include MF59 (oil-in-water emulsion of squalene); IC31 (cationic polyaminoacid KLK and oligodeoxynucleotide ODN1a); virosomes; GLA-SE (glucopyranosyl lipid adjuvant-stable emulsion); CAF (liposome-based cationic adjuvant formulations); CTB-CpG (CpG oligodeoxynucleotides conjugated to the nontoxic B subunit of cholera toxin); BCG (bacille Calmette-Geurin vaccine for TB).

    CREDIT: Y. HAMMOND/SCIENCE TRANSLATIONAL MEDICINE
  • Fig. 3.

    The matrix. ADITEC’s research activities are organized and carried out in 14 work packages (WPs). Each WP is managed by two independent coordinators, one for each tool and one for each scientific theme.

    CREDIT: Y. HAMMOND/SCIENCE TRANSLATIONAL MEDICINE

Additional Files

  • Supplementary Materials for

    ADITEC: Joining Forces for Next-Generation Vaccines

    Corresponding author. E‐mail: rino.rappuoli{at}novartis.com

    Published 4 April 2012, Sci.Transl. Med. 4, 128cm4 (2012)
    DOI: 10.1126/scitranslmed.3003826

    This PDF file includes:

    • Table S1. Key ADITEC data
    • Table S2. List of ADITEC participants
    • Table S3. ADITEC clinical trials

    [Download PDF]

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