Contents

Contents

• Commentary

  • ADITEC: Joining Forces for Next-Generation Vaccines

    By Rino Rappuoli, Donata Medaglini

    Science Translational Medicine04 Apr 2012 : 128cm4 Full AccessRestricted Access

    Through the Advanced Immunization Technologies project, scientists join forces to fashion next-generation vaccines with technologies that no lab can master alone.

    • Abstract
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• Research Articles

  • Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

    By Jeffrey Hrkach, Daniel Von Hoff, Mir Mukkaram Ali, Elizaveta Andrianova, Jason Auer, Tarikh Campbell, David De Witt, Michael Figa, Maria Figueiredo, Allen Horhota, Susan Low, Kevin McDonnell, Erick Peeke, Beadle Retnarajan, Abhimanyu Sabnis, Edward Schnipper, Jeffrey J. Song, Young Ho Song, Jason Summa, Douglas Tompsett, Greg Troiano, Tina Van Geen Hoven, Jim Wright, Patricia LoRusso, Philip W. Kantoff, Neil H. Bander, Christopher Sweeney, Omid C. Farokhzad, Robert Langer, Stephen Zale

    Science Translational Medicine04 Apr 2012 : 128ra39 Full AccessRestricted Access

    A targeted nanoparticle containing docetaxel displays antitumor activity in animals and differentiated pharmacological properties in patients with advanced solid tumors.

    • Editor's Summary
    • Abstract
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  • A Noncoding RNA Antisense to Moesin at 5p14.1 in Autism

    By Tara Kerin, Anita Ramanathan, Kasey Rivas, Nicole Grepo, Gerhard A. Coetzee, Daniel B. Campbell

    Science Translational Medicine04 Apr 2012 : 128ra40 Full AccessRestricted Access

    An antisense RNA, transcribed from an autism-associated region on chromosome 5, is highly expressed in autism brains and could regulate the developmental brain protein moesin.

    • Editor's Summary
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  • Serotonin Neuron Loss and Nonmotor Symptoms Continue in Parkinson’s Patients Treated with Dopamine Grafts

    By Marios Politis, Kit Wu, Clare Loane, Niall P. Quinn, David J. Brooks, Wolfgang H. Oertel, Anders Björklund, Olle Lindvall, Paola Piccini

    Science Translational Medicine04 Apr 2012 : 128ra41 Full AccessRestricted Access

    Dopamine-rich fetal tissue grafts relieve motor but not nonmotor symptoms in PD patients, requiring additional therapeutic interventions to treat continuing serotonergic denervation.

    • Editor's Summary
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  • T Cell Receptor αβ Diversity Inversely Correlates with Pathogen-Specific Antibody Levels in Human Cytomegalovirus Infection

    By George C. Wang, Pradyot Dash, Jonathan A. McCullers, Peter C. Doherty, Paul G. Thomas

    Science Translational Medicine04 Apr 2012 : 128ra42 Full AccessRestricted Access

    CD8⁺ T cell diversity may be more important than T cell abundance in limiting the negative consequences of cytomegalovirus persistence.

    • Editor's Summary
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• Editors' Choice

  • T Cells Gone Bad in Heart Disease

    By Aaron B. Baker

    Science Translational Medicine04 Apr 2012 : 128ec56 Full AccessRestricted Access

    An unusual type of immune cell may hold the key to preventing heart attacks.

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  • COBRA Insures Against Flu

    By Ruanne V. Barnabas

    Science Translational Medicine04 Apr 2012 : 128ec57 Full AccessRestricted Access

    Genomics and computational biology couple to build better broader flu vaccines.

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  • Tumors and Microbes, Sitting in a Tree…

    By Chetan Bettegowda

    Science Translational Medicine04 Apr 2012 : 128ec58 Full AccessRestricted Access

    Tumor-targeting bacteria are imaged using bioluminescent technology, shedding light on the heterogeneity of the tumor microenvironment.

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  • From Contagion to Outbreak: Host Susceptibility in Viral Pneumonia

    By Carolyn S. Calfee

    Science Translational Medicine04 Apr 2012 : 128ec59 Full AccessRestricted Access

    A minor allele of the IFITM3 gene may partially explain why some exposed people develop severe influenza infection, whereas others remain healthy.

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  • Diseases of Resistance

    By Takahisa Nakamura

    Science Translational Medicine04 Apr 2012 : 128ec60 Full AccessRestricted Access

    Can preventing insulin resistance in the brain help stop Alzheimer’s disease?

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