Contents
Vol 4, Issue 128
Contents
Commentary
- ADITEC: Joining Forces for Next-Generation Vaccines
Through the Advanced Immunization Technologies project, scientists join forces to fashion next-generation vaccines with technologies that no lab can master alone.
Research Articles
- Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile
A targeted nanoparticle containing docetaxel displays antitumor activity in animals and differentiated pharmacological properties in patients with advanced solid tumors.
- A Noncoding RNA Antisense to Moesin at 5p14.1 in Autism
An antisense RNA, transcribed from an autism-associated region on chromosome 5, is highly expressed in autism brains and could regulate the developmental brain protein moesin.
- Serotonin Neuron Loss and Nonmotor Symptoms Continue in Parkinson’s Patients Treated with Dopamine Grafts
Dopamine-rich fetal tissue grafts relieve motor but not nonmotor symptoms in PD patients, requiring additional therapeutic interventions to treat continuing serotonergic denervation.
- T Cell Receptor αβ Diversity Inversely Correlates with Pathogen-Specific Antibody Levels in Human Cytomegalovirus Infection
CD8+ T cell diversity may be more important than T cell abundance in limiting the negative consequences of cytomegalovirus persistence.
Editors' Choice
- T Cells Gone Bad in Heart Disease
An unusual type of immune cell may hold the key to preventing heart attacks.
- COBRA Insures Against Flu
Genomics and computational biology couple to build better broader flu vaccines.
- Tumors and Microbes, Sitting in a Tree…
Tumor-targeting bacteria are imaged using bioluminescent technology, shedding light on the heterogeneity of the tumor microenvironment.
- From Contagion to Outbreak: Host Susceptibility in Viral Pneumonia
A minor allele of the IFITM3 gene may partially explain why some exposed people develop severe influenza infection, whereas others remain healthy.
- Diseases of Resistance
Can preventing insulin resistance in the brain help stop Alzheimer’s disease?