04 April 2012
Vol 4, Issue 128

About The Cover

Cover image expansion

ONLINE COVER Smart Nanoparticles Target Tumors. Prostate cancer cells as well as the cells lining a tumor’s newly formed vasculature express a protein called PSMA on their surfaces. Hrkach and colleagues have designed smart nanoparticles that are decorated with a PSMA-targeting ligand, which allows the polymeric particles to home to tumors where they release a potent anticancer drug. This targeted approach was able to suppress tumor growth in several animal models and has shown early efficacy in patients with advanced solid tumors. [CREDIT: N. RAGER FULLER/SAYO ART]