21 March 2012
Vol 4, Issue 126
  • Contents

    • Perspective

      • Merging Systems Biology with Pharmacodynamics

        Enhanced pharmacodynamic models combine favorable features of systems biology and traditional models and may form the basis of precision medicine.

    • Research Articles

      • Characterization of Circulating Endothelial Cells in Acute Myocardial Infarction

        Features of endothelial cells in blood samples may eventually permit prediction of atherosclerotic plaque rupture events.

      • Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

        Prostaglandin D2 inhibits hair growth through its receptor, GPR44, and this pathway could serve as a new target for developing treatments for male pattern baldness.

      • Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to β-Lactam Antibiotics

        Methicillin-resistant Staphylococcus aureus infection can be treated effectively by combining a β-lactam antibiotic with a drug that targets FtsZ.

    • Editors' Choice

      • Twin Peaks

        Genetic factors regulate the brain’s high-frequency gamma waves, which are disrupted in schizophrenia.

      • A Painful Question of Metabolism

        Metabolomics analysis implicates altered sphingolipids in chronic neuropathic pain.

      • If I Had a Nickel for Every Wheeze

        Rhinovirus infection may exacerbate asthma symptoms by inducing type III interferon lambda.

About The Cover

Cover image expansion

ONLINE COVER Beating MRSA with a One-Two Punch. The cover shows colonies of methicillin-resistant Staphylococcus aureus (MRSA) grown in agar spiked with different antibiotics. Resistance of bacteria to β-lactam antibiotics, a mainstay of infectious disease treatment, continues to emerge and has resulted in MRSA becoming a major cause of mortality in hospitals. Tan et al. now show that a small molecule that blocks FtsZ, a vital component of MRSA's replication apparatus, not only stops the pathogen from growing but also renders it once again sensitive to β-lactam antibiotics. This one-two punch may be a valuable therapeutic strategy for combating MRSA in hospitals. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]