14 March 2012
Vol 4, Issue 125

About The Cover

Cover image expansion

ONLINE COVER A Better Fit. An improved anticoagulant drug called RUC-2 (ball and stick structure) fits snugly into its binding pocket on integrin (blue), a protein found on the surface of platelets. As described by Zhu et al., RUC-2 binds both subunits of integrin, inhibiting the excessive blood coagulation that can lead to strokes and heart attacks. Unlike similar drugs that alter integrin’s structure when they bind and trigger unwanted immune responses, RUC-2 does not disturb the configuration of its larger partner. [CREDIT: C. BICKEL/SCIENCE TRANSLATIONAL MEDICINE]